# Resolution of Ortner’s Syndrome Following Successful Mitral Transcatheter Edge-to-Edge Repair: The First Case Report

**Authors:** Ukachukwu I Okoro, Rajesh Varma, Benoy N Shah, Eunice N Onwordi

PMC · DOI: 10.7759/cureus.102949 · 2026-02-04

## TL;DR

An 82-year-old man with a rare voice disorder caused by heart issues showed significant improvement after a minimally invasive heart repair.

## Contribution

This is the first reported case of Ortner’s syndrome resolving after transcatheter mitral edge-to-edge repair.

## Key findings

- A patient with Ortner’s syndrome and severe mitral regurgitation showed vocal improvement after transcatheter repair.
- Transcatheter edge-to-edge mitral repair resolved both cardiac and vocal symptoms in this case.
- This case suggests that treating the underlying heart condition can reverse Ortner’s syndrome.

## Abstract

Ortner’s syndrome (OS), or cardiovocal syndrome, is an uncommon cause of hoarseness caused by recurrent laryngeal nerve palsy due to compression from underlying cardiovascular disease. It is classically associated with left atrial enlargement due to rheumatic mitral stenosis and, less frequently, severe mitral regurgitation. We present the case of an 82-year-old man with progressive dyspnea and hoarseness who was found to have severe mitral regurgitation and marked left atrial dilation. Following successful transcatheter edge-to-edge mitral repair, he experienced significant improvement in cardiac symptoms and vocal quality. To the best of our knowledge, this is the first reported case of OS resolving after transcatheter mitral edge-to-edge repair.

## Full-text entities

- **Diseases:** pulmonary congestion (MESH:D001261), nerve damage (MESH:D000080902), cardiovascular disease (MESH:D002318), rheumatic (MESH:D012216), congenital heart disease (MESH:D006330), hoarseness (MESH:D006685), atrial dilation (MESH:C563984), atrial enlargement (MESH:D006332), cardiac disease (MESH:D006331), Left atrial volume overload (MESH:D059446), pulmonary hypertension (MESH:D006976), dysphonia (MESH:D055154), thoracic aortic aneurysm (MESH:D017545), RLN compression (MESH:D061226), cardiovocal syndrome (MESH:D013577), compression (MESH:D009408), dyspnea (MESH:D004417), OS (MESH:D005359), aortic aneurysms (MESH:D001014), Mitral valve disease (MESH:D008946), left recurrent laryngeal nerve (RLN) palsy (MESH:D014826), anterior mitral valve (MESH:D008944)
- **Chemicals:** bumetanide (MESH:D002034)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12964495/full.md

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Source: https://tomesphere.com/paper/PMC12964495