Carbon dots penetrating the blood-brain barrier for central nervous system nanomedicine
Wubshet Mekonnen Girma, Girum Getachew Demissie, Shewaye Lakew Mekuria, Shamsa Kizhepat, T.M. Subrahmanya, Akash S. Rasal, Binyam Abdu Berhe, Gangaraju Gedda, Yoo-Jin Park, Jia-Yaw Chang, Myung-Geol Pang
TL;DR
Carbon dots can cross the blood-brain barrier and offer new ways to diagnose and treat central nervous system diseases.
Contribution
This review introduces carbon dots as a novel nanomedicine platform for CNS diseases by enabling BBB penetration and combined diagnostic and therapeutic functions.
Findings
Carbon dots can penetrate the blood-brain barrier through surface modifications.
Carbon dots support multimodal imaging and delivery of therapeutic agents for CNS diseases.
They offer combined diagnostic and therapeutic capabilities for brain disorders and cancers.
Abstract
Central nervous system (CNS) diseases are challenging to treat because of the blood-brain barrier (BBB), formed by tight junctions that limit the transcellular transport of therapeutic drugs. Carbon dots (CDs) have emerged as versatile nanotheranostic platforms for the targeting, diagnosis, and treatment of CNS diseases owing to their ultrasmall size, intrinsic photoluminescence, tunable surface chemistry, and biocompatibility. Surface modifications of CDs with targeting ligands, polymer coatings, biomimetic membranes, and exosome-like molecules enable BBB penetration and selective brain accumulation. CDs also support multimodal imaging techniques, such as fluorescence, magnetic resonance, and photoacoustic imaging, for early disease detection and real-time therapeutic monitoring. In addition, their ability to deliver drugs, genes, and therapeutic agents, combined with their…
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Taxonomy
TopicsCarbon and Quantum Dots Applications · Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications