# Necrotizing Fasciitis Camouflaging As Cellulitis: A Case Report Highlighting Diagnostic Pitfalls

**Authors:** Sakshi Palav, Shravan Gangula, Jyothi R Patri

PMC · DOI: 10.7759/cureus.104734 · Cureus · 2026-03-05

## TL;DR

This case report shows how necrotizing fasciitis can mimic cellulitis, emphasizing the need for early diagnosis and surgical intervention to prevent severe outcomes.

## Contribution

The report highlights diagnostic challenges and clinical clues for identifying necrotizing fasciitis in its early stages.

## Key findings

- Necrotizing fasciitis was initially mistaken for cellulitis due to similar early symptoms.
- Subcutaneous emphysema on imaging led to the correct diagnosis and urgent surgery.
- The case underscores the importance of considering NF in patients with disproportionate pain and risk factors.

## Abstract

Necrotizing fasciitis (NF) is a rapidly progressive, life-threatening soft tissue infection that is often misdiagnosed in its early stages due to clinical similarities with cellulitis. Early recognition and prompt surgical intervention are essential to reducing morbidity and mortality. This report presents one case of NF initially manifesting as cellulitis in a patient with multiple risk factors, including intravenous drug use and recent incarceration. Despite initial antibiotic therapy and transient clinical improvement, the patient experienced worsening pain and systemic symptoms. Imaging identified subcutaneous emphysema, leading to urgent surgical exploration that confirmed NF. This case highlights the importance of recognizing disproportionate pain, maintaining a high index of suspicion, and seeking early surgical consultation when NF is considered. The case was managed by family medicine residents and is presented to aid clinicians in recognizing and diagnosing NF among other potential conditions.

## Linked entities

- **Diseases:** necrotizing fasciitis (MONDO:0004835), cellulitis (MONDO:0005230)

## Full-text entities

- **Genes:** NFASC (neurofascin) [NCBI Gene 23114] {aka NEDCPMD, NF, NRCAML}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** gas gangrene (MESH:D005738), skin (MESH:D012871), disproportionate pain (MESH:D010146), bacteria (MESH:C000719206), peripheral vascular disease (MESH:D016491), hyperglycemia (MESH:D006943), soft-tissue infections (MESH:D018461), NF (MESH:D019115), abscess (MESH:D000038), inflammatory (MESH:D007249), swelling (MESH:D004487), emphysema (MESH:D004646), diabetes (MESH:D003920), substance use disorder (MESH:D019966), renal failure (MESH:D051437), Type I (MESH:D006969), necrotizing myositis (MESH:D009220), induration (MESH:D010411), bleeding (MESH:D006470), lymphadenopathy (MESH:D008206), fever (MESH:D005334), Neutrophilia (MESH:C563010), death (MESH:D003643), vascular thrombosis (MESH:D013927), hypocalcemia (MESH:D006996), leukocytosis (MESH:D007964), subcutaneous (MESH:D013352), deep venous thrombosis (MESH:D020246), toxicity (MESH:D064420), spider bite (MESH:D001098), Type II infections (MESH:D007239), tenderness (MESH:D063806), renal dysfunction (MESH:D007674), bacterial infection (MESH:D001424), Cellulitis (MESH:D002481), left forearm lesion (MESH:D005543), infectious disease (MESH:D003141), Tissue damage (MESH:D017695), septic arthritis (MESH:D001170), cutaneous gangrene (MESH:D005734), erythema (MESH:D004890), hemodynamic instability (MESH:D043171), necrosis (MESH:D009336)
- **Chemicals:** Ibuprofen (MESH:D007052), vancomycin (MESH:D014640), sodium (MESH:D012964), Hematoxylin (MESH:D006416), heroin (MESH:D003932), Norco (-), Zosyn (MESH:D000077725), Bactrim (MESH:D015662), Unasyn (MESH:C035444), creatinine (MESH:D003404), glucose (MESH:D005947), gabapentin (MESH:D000077206), eosin (MESH:D004801), warfarin (MESH:D014859)
- **Species:** Prevotella intermedia (species) [taxon 28131], Streptococcus (genus) [taxon 1301], Homo sapiens (human, species) [taxon 9606], Staphylococcus aureus (species) [taxon 1280], Peptostreptococcus (genus) [taxon 1257]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12964327/full.md

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Source: https://tomesphere.com/paper/PMC12964327