# Upadacitinib for Immune Checkpoint Inhibitor–Related Dermatitis: A Nonrandomized Clinical Trial

**Authors:** Chengshui Chen, Xinyu Liang, Zheng Peng, Yan Zou, Huijuan He, Xiaoyan Zhang, Yi He, Shixiu Wu

PMC · DOI: 10.1001/jamaoncol.2026.0136 · JAMA Oncology · 2026-03-05

## TL;DR

This study explores using upadacitinib to treat severe skin reactions caused by cancer immunotherapy drugs.

## Contribution

The study evaluates upadacitinib as a potential treatment for immune checkpoint inhibitor–related dermatitis in a clinical trial setting.

## Key findings

- Oral upadacitinib was assessed for safety and efficacy in treating severe immune checkpoint inhibitor–related dermatitis.
- The trial provides insights into managing dermatitis caused by cancer immunotherapy.

## Abstract

This nonrandomized clinical trial examines the safety and efficacy of oral upadacitinib in the treatment of patients with severe immune checkpoint inhibitor–related dermatitis.

## Linked entities

- **Chemicals:** upadacitinib (PubChem CID 58557659)
- **Diseases:** dermatitis (MONDO:0002406)

## Full-text entities

- **Diseases:** Dermatitis (MESH:D003872)
- **Chemicals:** Upadacitinib (MESH:C000613732)

## Full text

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## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12964249/full.md

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Source: https://tomesphere.com/paper/PMC12964249