# Upadacitinib for recalcitrant extraintestinal Crohn disease

**Authors:** Avery H. Seward, Jeffrey P. Callen

PMC · DOI: 10.1016/j.jdcr.2025.11.031 · JAAD Case Reports · 2026-01-17

## Full-text entities

- **Genes:** JAK1 (Janus kinase 1) [NCBI Gene 3716] {aka AIIDE, JAK1A, JAK1B, JTK3}
- **Diseases:** ulcerative (MESH:D014456), genital swelling (MESH:D004487), Crohn (MESH:D003424), hypertrophy (MESH:D006984), skin lesions (MESH:D012871), granulomatous inflammation (MESH:D007249), ulcerative slit (MESH:D056124), rheumatoid arthritis (MESH:D001172), ulcerative colitis (MESH:D003093), psoriatic arthritis (MESH:D015535), hand lesion (MESH:D006232), extra-intestinal Crohn (MESH:D007410), atopic dermatitis (MESH:D003876), erythema (MESH:D004890), hypersensitivity (MESH:D004342), noncaseating granulomas (MESH:D006099), bowel disease (MESH:D015212), lesions (MESH:D009059)
- **Chemicals:** silver sulfadiazine (MESH:D012837), metronidazole (MESH:D008795), hydrocortisone (MESH:D006854), ustekinumab (MESH:D000069549), Upadacitinib (MESH:C000613732), QuantiFERON-TB (-), mycophenolate mofetil (MESH:D009173), triamcinolone (MESH:D014221), methotrexate (MESH:D008727)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12964233/full.md

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Source: https://tomesphere.com/paper/PMC12964233