# Familial CARD14-associated papulosquamous eruption with a novel mutation successfully treated with secukinumab **Authors:** Jieru Ren, Guozhen Tan, Zhenrui Shi PMC · DOI: 10.1016/j.jdcr.2026.01.047 · JAAD Case Reports · 2026-02-03 ## Full-text entities - **Genes:** IL17A (interleukin 17A) [NCBI Gene 3605] {aka CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17}, IL23A (interleukin 23 subunit alpha) [NCBI Gene 51561] {aka IL-23, IL-23A, IL23P19, P19, SGRF}, CARD14 (caspase recruitment domain family member 14) [NCBI Gene 79092] {aka BIMP2, CARMA2, PRP, PSORS2, PSS1}, IVL (involucrin) [NCBI Gene 3713], NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, TGM1 (transglutaminase 1) [NCBI Gene 7051] {aka ARCI1, ICR2, KTG, LI, LI1, TGASE} - **Diseases:** palmoplantar keratoderma (MESH:D007645), autosomal-dominant inflammatory dermatosis (MESH:D012871), pityriasis rubra pilaris (MESH:D010916), inflammation (MESH:D007249), hyperkeratosis (MESH:D017488), ectropion (MESH:D004483), eruptions (MESH:D003875), papules (MESH:D000169), bleeding (MESH:D006470), pruritus (MESH:D011537), CAPE (MESH:D017444), parakeratosis (MESH:D010241), erythema (MESH:D004890), epidermal hyperplasia (MESH:D006965), psoriasis (MESH:D011565), acanthosis (MESH:D000052) - **Chemicals:** ustekinumab (MESH:D000069549), guselkumab (MESH:C000588857), sulfur (MESH:D013455), Ixekizumab (MESH:C549079), retinoids (MESH:D012176), secukinumab (MESH:C555450), erythromycin (MESH:D004917) - **Species:** Homo sapiens (human, species) [taxon 9606] - **Mutations:** p.Met119Lys, c.356T>A, c.349+2T>C ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12964217/full.md ## Figures 2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12964217/full.md ## References 10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12964217/full.md --- Source: https://tomesphere.com/paper/PMC12964217