# Norwegian consensus guidelines for selection of neuro-oncology patients to proton therapy

**Authors:** Liv Cathrine Heggebø, Tor-Christian Aase Johannessen, Henriette Magelssen, Mette Sprauten, Hanne Blakstad, Jorunn Brekke, Dorota Goplen, Kirsten Marienhagen, Tora S. Solheim, Line Bjorland, Petter Brandal

PMC · DOI: 10.1016/j.ctro.2026.101140 · Clinical and Translational Radiation Oncology · 2026-02-25

## TL;DR

This paper presents Norwegian guidelines for selecting neuro-oncology patients for proton therapy, based on limited evidence and early patient data.

## Contribution

The paper introduces the first Norwegian consensus guidelines for neuro-oncology patient selection for proton therapy.

## Key findings

- Guidelines were developed through literature review and nationwide discussions.
- An overview of patients receiving proton therapy was recorded in the first six months of facility operation.

## Abstract

•Norwegian consensus guideline for neurooncology patient selection to proton therapy.•Very limited evidence on which patients benefit most from proton therapy.•Overview of patients offered proton therapy the first months of facility operation.

Norwegian consensus guideline for neurooncology patient selection to proton therapy.

Very limited evidence on which patients benefit most from proton therapy.

Overview of patients offered proton therapy the first months of facility operation.

With the launch of two Norwegian proton facilities, Norwegian Neuro-Oncology Interest Group developed consensus guidelines for selection of neuro-oncology patients to proton therapy. Relevant literature review and nationwide discussions informed the process. An overview of patients offered proton therapy during the first six months of operation was registered.

## Full-text entities

- **Genes:** IDH1 (isocitrate dehydrogenase (NADP(+)) 1) [NCBI Gene 3417] {aka HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC}
- **Diseases:** neurological deficits (MESH:D009461), PitNET (MESH:D018358), oligodendrogliomas (MESH:D009837), neoplasms (MESH:D009369), gliomas (MESH:D005910), neuro-oncological neoplastic (MESH:D000072716), cognitive decline (MESH:D003072), astrocytomas (MESH:D001254), intracranial neoplasms (MESH:D001932), NF (MESH:D016518), PBT (MESH:D016609), toxicity (MESH:D064420), neurofibromatosis (MESH:D017253), meningioma (MESH:D008579)
- **Chemicals:** proton (MESH:D011522)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12963899/full.md

## References

48 references — full list in the complete paper: https://tomesphere.com/paper/PMC12963899/full.md

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Source: https://tomesphere.com/paper/PMC12963899