# Editorial: The role of calcium channels in human health and disease, volume III

**Authors:** Peng Zhang, Chang-Bo Zheng, Zhen Chen, Xiao-Yu Liu

PMC · DOI: 10.3389/fmolb.2026.1803665 · Frontiers in Molecular Biosciences · 2026-02-20

## Full-text entities

- **Genes:** PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)) [NCBI Gene 9780] {aka DHS, ER, FAM38A, LMPH3, LMPHM6, Mib}, ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3) [NCBI Gene 489] {aka SERCA3}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, TRPV2 (transient receptor potential cation channel subfamily V member 2) [NCBI Gene 51393] {aka VRL, VRL-1, VRL1}, TRPV1 (transient receptor potential cation channel subfamily V member 1) [NCBI Gene 7442] {aka VR1}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, KCNK4 (potassium two pore domain channel subfamily K member 4) [NCBI Gene 50801] {aka FHEIG, K2p4.1, TRAAK, TRAAK1}, ANO1 (anoctamin 1) [NCBI Gene 55107] {aka DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A}, RYR1 (ryanodine receptor 1) [NCBI Gene 6261] {aka CCO, CMYO1A, CMYO1B, CMYP1A, CMYP1B, KDS}, NOX3 (NADPH oxidase 3) [NCBI Gene 50508] {aka GP91-3, MOX-2}, TRPV4 (transient receptor potential cation channel subfamily V member 4) [NCBI Gene 59341] {aka BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA}, RYR2 (ryanodine receptor 2) [NCBI Gene 6262] {aka ARVC2, ARVD2, RYR-2, RyR, VACRDS, VTSIP}, CDH18 (cadherin 18) [NCBI Gene 1016], MAPK1 (mitogen-activated protein kinase 1) [NCBI Gene 5594] {aka ERK, ERK-2, ERK2, ERT1, MAPK2, NS13}, IGF1R (insulin like growth factor 1 receptor) [NCBI Gene 3480] {aka CD221, IGFIR, IGFR, JTK13}, DNAH8 (dynein axonemal heavy chain 8) [NCBI Gene 1769] {aka ATPase, SPGF46, hdhc9}, TRPC1 (transient receptor potential cation channel subfamily C member 1) [NCBI Gene 7220] {aka HTRP-1, TRP1}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}
- **Diseases:** pain (MESH:D010146), neoplastic diseases (MESH:D004194), neurodegenerative diseases (MESH:D019636), inflammation (MESH:D007249), sarcopenia (MESH:D055948), metabolic syndrome (MESH:D024821), cerebral ischemia (MESH:D002545), cancers (MESH:D009369), arrhythmias (MESH:D001145), HNSCC (MESH:D000077195), hypertension (MESH:D006973), endometrial carcinoma (MESH:D016889), CRC (MESH:D015179), epilepsy (MESH:D004827), reperfusion injury (MESH:D015427), metastasis (MESH:D009362), ototoxicity (MESH:D006311), insulin resistance (MESH:D007333), cardiovascular disease (MESH:D002318), catecholaminergic polymorphic ventricular tachycardia (MESH:C536334), muscle deterioration (MESH:D009135), glaucoma (MESH:D005901), neuronal damage (MESH:D009410), channel dysfunction (MESH:D020513), miscarriage (MESH:D000022), calcium channel dysfunction (MESH:D002128), breast cancer (MESH:D001943), glioblastoma (MESH:D005909), diseases related to the nervous system (MESH:D009422), glucose intolerance (MESH:D018149), necrosis (MESH:D009336)
- **Chemicals:** N (MESH:D009584), K (MESH:D011188), panaxadiol (MESH:C004564), cisplatin (MESH:D002945), BaoTaiYin (-), bile acid (MESH:D001647), Tranilast (MESH:C012293), Calcium (MESH:D002118), Mibefradil (MESH:D020748)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

## Full text

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## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12963871/full.md

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Source: https://tomesphere.com/paper/PMC12963871