# Retraction: The intra-nuclear SphK2-S1P axis facilitates M1-to-M2 shift of microglia via suppressing HDAC1-mediated KLF4 deacetylation

PMC · DOI: 10.3389/fimmu.2026.1809852 · Frontiers in Immunology · 2026-02-20

## Full-text entities

- **Genes:** MBTPS1 (membrane bound transcription factor peptidase, site 1) [NCBI Gene 8720] {aka CAOP, PCSK8, S1P, SEDKF, SKI-1}, HDAC1 (histone deacetylase 1) [NCBI Gene 3065] {aka GON-10, HD1, KDAC1, RPD3, RPD3L1}, KLF4 (KLF transcription factor 4) [NCBI Gene 9314] {aka EZF, GKLF}, SPHK2 (sphingosine kinase 2) [NCBI Gene 56848] {aka SK 2, SK-2, SPK 2, SPK-2}

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Source: https://tomesphere.com/paper/PMC12963759