# Tumor Suppressor p53 and MicroRNAs Interaction in Breast Cancer

## TL;DR

This paper reviews how p53 and microRNAs interact in breast cancer, highlighting their roles in disease progression and potential for new treatments.

## Contribution

The paper provides a comprehensive literature review on the mutual regulation between p53 and miRNAs in breast cancer.

## Key findings

- TP53 gene expression is modulated by miRNAs like miR-30c, miR-34a, and miR-200 family, which can silence tumor suppressor effects.
- p53 protein can regulate miRNAs such as miR-146a, miR-192, and miR-200 family, influencing breast cancer aggressiveness.
- Understanding p53-miRNA interactions may lead to new biomarkers and targeted therapies for breast cancer.

## Abstract

This literature review explores the complex interaction between p53 and microRNAs (miRNAs) in the occurrence and progression of breast cancer (BC), the most common and lethal tumor type among women. BC is a multifactorial disease resulting from a combination of genetic and epigenetic alterations in cell DNA, influencing proliferation, differentiation, and migration. TP53 gene, which codifies p53 protein, is a known tumor suppressor, and it plays an important role in cell maintenance as DNA repair, cell proliferation control, and apoptosis activation. TP53 expression can be modulated by several miRNAs, as miR-30c, miR-34a, and the miR-200 family, inhibiting p53 production and silencing its tumor suppressor effects. On the other hand, p53 protein can modulate several miRNAs expression, as miR-146a, miR-192, and the miR-200 family, by acting as a transcription factor or by modulating miRNA processing, interfering with BC aggressiveness and progression. Understanding the role of p53 and miRNAs in BC may aid in identifying new biomarkers and developing new targeted therapies for patient treatment.