# Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

## TL;DR

This paper reviews LSDV inhibitors, focusing on virus biology, drug repurposing, and computer-aided design to help develop new antiviral treatments.

## Contribution

The paper systematically compiles LSDV inhibitors and discusses computer-aided drug design for antiviral discovery.

## Key findings

- The paper summarizes LSDV's biological characteristics and key proteins in its replication cycle.
- It reviews direct-acting and host-directed poxvirus inhibitors and their mechanisms.
- Computer-aided drug design is highlighted as a promising approach for discovering new LSDV inhibitors.

## Abstract

This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and potential targets, aiming to provide references for the development of LSDV inhibitors. Additionally, the application of computer‐aided drug design methods in anti‐LSDV inhibitor research is discussed, offering insights from the perspective of virtual screening to facilitate the discovery of novel antiviral agents.