# Polyamines as a Universal Language of Host–Microbiota Symbiosis

## TL;DR

Polyamines, produced by gut microbes and influenced by the host, play a key role in maintaining health and treating diseases like inflammatory bowel disease.

## Contribution

The paper highlights polyamines as a central mediator in host-microbiota interactions with therapeutic potential.

## Key findings

- Polyamines support epithelial integrity and immune regulation.
- Disruption of polyamine metabolism worsens inflammation and barrier dysfunction.
- Engineered therapies targeting polyamine metabolism show promise for treating age-related diseases.

## Abstract

Polyamines are ancient metabolites that serve critical functions in maintaining epithelial integrity, regulating immune response, and supporting healthy aging. The gut microbiota actively synthesizes and converts polyamines, while host factors such as inflammation, barrier function, and nutritional status dynamically modulate this metabolic network. Disruption of this host–microbiota axis reduces polyamine availability, impairs barrier function, and exacerbates inflammation. In contrast, polyamines exert protective effects by promoting epithelial repair, modulating macrophage and T-cell responses, and enhancing autophagy-mediated tissue renewal and longevity. Recent advances in engineered probiotics, microbial small RNAs, and postbiotics further highlight the therapeutic potential of precisely modulating polyamine metabolism in clinical contexts such as inflammatory bowel disease, metabolic syndrome, and neurodegenerative conditions associated with aging.