# Incisional Hernia Development: Wound Healing Gone Wrong?

**Authors:** Asim A. Abbas, Paul Gunning, Srinivas Chintapatla, Roland Kröger

PMC · DOI: 10.1111/wrr.70131 · Wound Repair and Regeneration · 2026-03-05

## TL;DR

This paper explores why incisional hernias occur after abdominal surgery, focusing on how incisions affect the healing and strength of the abdominal wall.

## Contribution

The paper offers a comprehensive review of the ultrastructure of the abdominal wall and how incisions compromise its mechanical integrity.

## Key findings

- Incisional hernias remain a significant clinical issue despite advances in surgical techniques.
- Understanding the ultrastructure of the abdominal wall is crucial for improving wound healing outcomes.
- The mechanical integrity of the abdominal wall is notably affected by surgical incisions.

## Abstract

Incisional hernia (IH) is a common complication of abdominal surgeries, characterised by the protrusion of abdominal contents through a weakened surgical scar. Despite advancements in surgical techniques and biomaterials, IH remains a significant clinical and economic burden, with recurrence rates reaching up to 32% after repair. This unusually high number, despite many years of research focused on the improvement of surgical techniques, requires a better understanding of the potential origins of IH occurrence. This must implicate the tissues involved in scar formation of the abdominal wall for a better understanding of how these tissues are affected by the incision and what can potentially affect the most optimal wound healing. This work aimed to provide a comprehensive summary of the current knowledge regarding the ultrastructure of the abdominal wall and how incisions affect its mechanical integrity.

## Full-text entities

- **Genes:** LOX (lysyl oxidase) [NCBI Gene 4015] {aka AAT10}, ELN (elastin) [NCBI Gene 2006] {aka ADCL1, SVAS, WBS, WS}, COL1A1 (collagen type I alpha 1 chain) [NCBI Gene 1277] {aka CAFYD, EDSARTH1, EDSC, OI1, OI2, OI3}, COL3A1 (collagen type III alpha 1 chain) [NCBI Gene 1281] {aka EDS4A, EDSVASC, PMGEDSV}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, PC (pyruvate carboxylase) [NCBI Gene 5091] {aka PCB}, TIMP1 (TIMP metallopeptidase inhibitor 1) [NCBI Gene 7076] {aka CLGI, EPA, EPO, HCI, TIMP, TIMP-1}, FN1 (fibronectin 1) [NCBI Gene 2335] {aka CIG, ED-B, FINC, FN, FNZ, GFND}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, RUNX2 (RUNX family transcription factor 2) [NCBI Gene 860] {aka AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** linea alba (MESH:C567402), ligament mineralisation (MESH:D000082122), chronic (MESH:D002908), bony (MESH:D018213), herniation (MESH:D004677), rigidity (MESH:D009127), collagen (MESH:D003095), chronic pain (MESH:D059350), abdominal (MESH:D000007), wound infection (MESH:D014946), ossification of (MESH:C562735), Hernia (MESH:D006547), CAWR (MESH:D046449), Connective Tissue Disorder (MESH:D003240), Chronic tendinopathy (MESH:D052256), IHs (MESH:C535746), atherosclerosis (MESH:D050197), arthritis (MESH:D001168), spinal ligament calcification (MESH:D017887), burn (MESH:D002056), vomiting (MESH:D014839), ischaemia (MESH:D007511), genetic defects (MESH:D030342), COPD (MESH:D029424), hernia scars (MESH:D002921), Myositis ossificans (MESH:D009221), Obesity (MESH:D009765), HO (MESH:D009999), midline and ventral hernias (MESH:D006555), swelling (MESH:D004487), blood loss (MESH:D016063), aortic aneurysms (MESH:D001014), scar failure (MESH:D051437), tendon rupture (MESH:D012421), diabetes (MESH:D003920), Calcification (MESH:D002114), malignancies (MESH:D009369), haemostasis (MESH:D020141), pain (MESH:D010146), inguinal hernia (MESH:D006552), fasciitis ossificans (MESH:D005208), respiratory disease (MESH:D012140), IH (MESH:D000069290), trauma (MESH:D014947), bowel obstruction (MESH:D012778), Inflammatory (MESH:D007249), Ehlers-Danlos syndrome (MESH:D004535), fibrosis (MESH:D005355), nephrolithiasis (MESH:D053040)
- **Chemicals:** hydroxylysine (MESH:D006901), bisphosphonates (MESH:D004164), calcium (MESH:D002118), lysine (MESH:D008239), lipid (MESH:D008055), hydroxyproline (MESH:D006909), anti (-), water (MESH:D014867), apatite (MESH:D001031), relaxin (MESH:D012065), phosphate (MESH:D010710), doxycycline (MESH:D004318), carbonate (MESH:D002254)
- **Species:** Bos taurus (bovine, species) [taxon 9913], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12963529/full.md

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12963529/full.md

## References

74 references — full list in the complete paper: https://tomesphere.com/paper/PMC12963529/full.md

---
Source: https://tomesphere.com/paper/PMC12963529