# Multi-adapter SAM-inspired bronchoscopic image segmentation for lung cancer diagnosis

**Authors:** Qian Li, Xinbo Liu, Chao Ye, Sen Cui, Jinze Zhang, Xuanyu Meng, Jin Guo, Xianjun Min

PMC · DOI: 10.3389/fonc.2026.1706202 · Frontiers in Oncology · 2026-02-20

## TL;DR

This paper introduces MASA, a new AI model that improves lung cancer detection during bronchoscopy by combining lesion segmentation and diagnosis in one system.

## Contribution

MASA is the first end-to-end framework that unifies bronchoscopic lesion segmentation and cancer diagnosis using a dual decoder.

## Key findings

- MASA outperformed ESFPNet in lesion segmentation with +3.01% mDice and +1.24% mIoU improvements.
- MASA improved diagnosis with +8.1 Macro-F1 and +14.1 AUPRC gains.
- MASA provides pixel-level lesion maps and case-level predictions for clinical use.

## Abstract

Lung cancer remains the leading cause of cancer-related mortality. Although bronchoscopy allows direct visualization and tissue sampling, detecting subtle lesions is still challenging owing to limited resolution, variable imaging conditions, and the complex structure of the airway. Most existing approaches treat lesion segmentation and cancer diagnosis as separate tasks, which can reduce diagnostic coherence and limit clinical applicability.

We propose a novel Multi-Adapter-based Segment Any Bronchoscope Model (MASA), an end-to-end framework with an encoder that fuses spatial, frequency, and positional information and a dual decoder that performs simultaneous lesion segmentation and lung cancer diagnosis. MASA was trained/evaluated on the public BM-BronchoLC dataset.

On BM-BronchoLC, MASA improved lesion segmentation over the strongest baseline (ESFPNet), raising mean Dice coefficient (mDice) by +3.01% and mean Intersection-over-Union (mIoU) by +1.24%. For diagnosis, MASA increased Macro-F1 by +8.1 points and area under the precision–recall curve (AUPRC) by +14.1%.

MASA provides a unified and interpretable pipeline for automated bronchoscopic image analysis, generating pixel-level lesion maps alongside case-level diagnostic predictions. The framework shows strong promise for improving early lung cancer detection and enhancing the efficiency of bronchoscopic workflows in clinical practice.

## Linked entities

- **Diseases:** lung cancer (MONDO:0005138)

## Full-text entities

- **Diseases:** GI cancers (MESH:D005770), colorectal polyps (MESH:D003111), Lesion (MESH:D009059), polyp (MESH:D011127), Lung cancer (MESH:D008175), GI lesion (MESH:D005767), Cancer (MESH:D009369)
- **Chemicals:** CY (MESH:D003545), MASA (MESH:C042762), HOPE (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12962954/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12962954/full.md

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Source: https://tomesphere.com/paper/PMC12962954