# Radial glia at the neurovascular interface during cortical development

## TL;DR

This paper explores how radial glia interact with the developing blood vessels in the brain during cortical development.

## Contribution

The paper highlights novel insights into the crosstalk between radial glia and endothelial cells during cortical development.

## Key findings

- Radial glia interact dynamically with the cortical vasculature during development.
- The spatial relationship between radial glia and endothelial cells influences radial glial biology.
- Angiogenic processes and environmental cues regulate radial glia behavior.

## Abstract

Radial glia are a specialized population of neural progenitor cells that persist throughout embryogenesis and into adulthood. Throughout this period, radial glia reside in a highly dynamic microenvironment that influences various biological decisions that govern typical cortical development. Subsequently, radial glia must fine-tune their responses to numerous environmental cues throughout development. The establishment of the cortical vasculature coincides with neurogenesis and dramatically alters the radial glia microenvironment by increasing oxygen and metabolite delivery. In addition, a synergistic spatial relationship between radial glia and endothelial cells regulates multiple aspects of radial glial biology. Here, we discuss crosstalk between radial glia and the cortical vasculature/endothelial cells throughout development, including the influence of extrinsic angiogenic processes and our growing understanding of the intricate spatial relationships between radial glia and endothelial cells.