# Case Report: Surgical resection combined with chemotherapy for a primary cardiac lymphoma involving right heart structures

**Authors:** Wei Zhu, Xinying Ren, Hanrui Xiong, Man Chen, Boxiang Huang, Bo Peng, Dongqun Lin, Xiaoping Fan

PMC · DOI: 10.3389/fonc.2026.1732411 · Frontiers in Oncology · 2026-02-20

## TL;DR

A 67-year-old woman with primary cardiac lymphoma was successfully treated with surgery and chemotherapy, showing no recurrence after 8 months.

## Contribution

This case report highlights the successful use of surgical resection combined with Pola-R-CHP chemotherapy for primary cardiac lymphoma.

## Key findings

- Surgical resection confirmed the diagnosis of primary cardiac lymphoma in a 67-year-old woman.
- Postoperative chemotherapy with Pola-R-CHP led to no recurrence of the disease after 8 months.
- Multimodal treatment including surgery and chemotherapy achieved satisfactory results in this rare case.

## Abstract

Primary cardiac lymphoma is a highly rare type of malignant tumor that originates from the lymphoid tissue within the heart or pericardium. Surgical treatment is the primary method for obtaining pathological results and relieving obstructions, and chemotherapy is the main method for disease control. We present a case of a 67-year-old woman diagnosed with primary cardiac lymphoma, presenting with shortness of breath and bilateral lower extremity edema after activity. Multimodality imaging results suggest a primary cardiac lymphoma, which was located in the right atrioventricular groove. Surgical resection of the mass was performed and histopathology confirmed the diagnosis of primary cardiac lymphoma. Based on the genetic results, Pola-R-CHP was used for postoperative chemotherapy. Fortunately, no evidence of recurrence of primary cardiac lymphoma was showed 8 months after surgery. Surgical resection combined with chemotherapy has achieved satisfactory results in the treatment of primary cardiac lymphoma.

## Linked entities

- **Diseases:** primary cardiac lymphoma (MONDO:0003917)

## Full-text entities

- **Genes:** IGH (immunoglobulin heavy locus) [NCBI Gene 3492] {aka IGD1, IGH.1@, IGH@, IGHD@, IGHDY1, IGHJ}, CHP1 (calcineurin like EF-hand protein 1) [NCBI Gene 11261] {aka CHP, SLC9A1BP, SPAX9, Sid470p, p22, p24}, CD79A (CD79a molecule) [NCBI Gene 973] {aka IGA, IGAlpha, MB-1, MB1}, CD38 (CD38 molecule) [NCBI Gene 952] {aka ADPRC 1, ADPRC1, cADPR1}, DNTT (DNA nucleotidylexotransferase) [NCBI Gene 1791] {aka TDT}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}, BCPR [NCBI Gene 8142], KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, BCL6 (BCL6 transcription repressor) [NCBI Gene 604] {aka BCL5, BCL6A, LAZ3, ZBTB27, ZNF51}, MME (membrane metalloendopeptidase) [NCBI Gene 4311] {aka CALLA, CD10, CMT2T, NEP, SCA43, SFE}, MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}, SDC1 (syndecan 1) [NCBI Gene 6382] {aka CD138, SDC, SYND1, syndecan}, CD34 (CD34 molecule) [NCBI Gene 947], IGL (immunoglobulin lambda locus) [NCBI Gene 3535] {aka IGL@}, CD58 (CD58 molecule) [NCBI Gene 965] {aka LFA-3, LFA3, ag3}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, CCND1 (cyclin D1) [NCBI Gene 595] {aka BCL1, D11S287E, PRAD1, U21B31}, PIM1 (Pim-1 proto-oncogene, serine/threonine kinase) [NCBI Gene 5292] {aka PIM}, CD5 (CD5 molecule) [NCBI Gene 921] {aka LEU1, T1}, H1-4 (H1.4 linker histone, cluster member) [NCBI Gene 3008] {aka H1.4, H1E, H1F4, H1s-4, HIST1H1E, RMNS}, IGK (immunoglobulin kappa locus) [NCBI Gene 50802] {aka IGK@}, CR2 (complement C3d receptor 2) [NCBI Gene 1380] {aka C3DR, CD21, CR, CVID7, SLEB9}, FCER2 (Fc epsilon receptor II) [NCBI Gene 2208] {aka BLAST-2, CD23, CD23A, CLEC4J, FCE2, FCErII}, BCL7A (BAF chromatin remodeling complex subunit BCL7A) [NCBI Gene 605] {aka BCL7, SMARCJ1}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, PWWP3A (PWWP domain containing 3A, DNA repair factor) [NCBI Gene 84939] {aka EXPAND1, HSPC211, MUM-1, MUM1}
- **Diseases:** conduction (MESH:D054537), cardiac murmurs (MESH:D006337), lower extremity edema (MESH:D004487), cardiac arrest (MESH:D006323), malignancy (MESH:D009369), neurotoxic (MESH:D020258), dyspnea (MESH:D004417), syncope (MESH:D013575), cardiac tamponade (MESH:D002305), cardiac tumors (MESH:D006338), ventricular fibrillation (MESH:D014693), neurological symptoms (MESH:D009461), DLBCL (MESH:D016403), extranodal non-Hodgkin lymphoma (MESH:D008228), coronary artery compression (MESH:D003324), peripheral neuropathy (MESH:D010523), -wave abnormalities (MESH:C535500), chest pain (MESH:D002637), CMV (MESH:D003586), arrhythmias (MESH:D001145), B-cell lymphoma (MESH:D016393), Primary cardiac lymphoma (MESH:D008223), lymphomatous (MESH:D013967)
- **Chemicals:** R (MESH:D001120), rituximab (MESH:D000069283), dexamethasone (MESH:D003907), epirubicin (MESH:D015251), CHOP (-), cyclophosphamide (MESH:D003520), polatuzumab vedotin (MESH:C000600736), chidamide (MESH:C547816)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12962886/full.md

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Source: https://tomesphere.com/paper/PMC12962886