# Case Report: Pansteatitis with sterile nodular panniculitis (SNP) in a dog

**Authors:** Jihee Han, Yenah Lee, Youngsin Seung, Kunho Song

PMC · DOI: 10.3389/fvets.2026.1681878 · Frontiers in Veterinary Science · 2026-02-20

## TL;DR

A 3-year-old dog was diagnosed with and successfully treated for a rare condition involving inflammation of fat tissue, using minimally invasive methods.

## Contribution

This is the first reported case of sterile nodular panniculitis and pansteatitis diagnosed and treated using minimally invasive techniques.

## Key findings

- Computed tomography and laparoscopic biopsy confirmed the diagnosis of sterile nodular panniculitis and pansteatitis in a dog.
- Glucocorticoid therapy led to significant improvement in subcutaneous nodules and clinical symptoms.
- The dog remained asymptomatic and without recurrence after discontinuation of treatment.

## Abstract

A 3-year-old, castrated male Jindo dog presented with a 5-day history of pyrexia, lethargy, anorexia, and abdominal pain. Physical examination revealed multiple subcutaneous nodules, and abdominal ultrasonography showed numerous intra-abdominal nodules. Computed tomography (CT) identified widespread subcutaneous fatty nodules with fat stranding and multiple poorly defined nodular lesions within the abdominal fat. Histopathological examination confirmed panniculitis and steatitis, with no infectious agents identified. Based on these findings, a final diagnosis of sterile nodular panniculitis (SNP) and pansteatitis was made, and the dog was treated with glucocorticoids. Follow-up CT performed 4 months after the initiation of therapy showed marked improvement in the subcutaneous nodules, with only a few residual intra-abdominal lesions remaining. As the dog remained clinically asymptomatic, glucocorticoid therapy was discontinued. At the time of writing, no clinical recurrence had been observed. This is the first reported case in which sterile nodular panniculitis and pansteatitis were diagnosed and treated using minimally invasive approaches, including whole-body computed tomography and laparoscopic biopsy.

## Linked entities

- **Species:** Canis lupus familiaris (taxon 9615)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 488629], ALPL (alkaline phosphatase, biomineralization associated) [NCBI Gene 403548] {aka ALP}, PTHLH (parathyroid hormone like hormone) [NCBI Gene 403987] {aka PTHRP}, A2M (alpha-2-macroglobulin) [NCBI Gene 477699], PNLIPRP1 (pancreatic lipase related protein 1) [NCBI Gene 404010] {aka PLRP1}, SERPINA1 (serpin family A member 1) [NCBI Gene 480422], PNLIP (pancreatic lipase) [NCBI Gene 477830], PTH (parathyroid hormone) [NCBI Gene 403986]
- **Diseases:** depression (MESH:D003866), SNP (MESH:D010201), adipocyte necrosis (MESH:D009336), atopic dermatitis (MESH:D003876), Pancreatic diseases (MESH:D010182), fungal (MESH:D009181), infectious diseases (MESH:D003141), SFTS (MESH:D000085142), vitamin E deficiency (MESH:D014811), polyarthritis (MESH:D001168), Panniculitis (MESH:D015434), peritoneal effusion (MESH:D010538), infections (MESH:D007239), lethargy (MESH:D053609), hypercalcemia (MESH:D006934), dehydration (MESH:D003681), granulomatous lesions (MESH:D006105), immune-mediated (MESH:C567355), diarrhea (MESH:D003967), cutaneous lupus erythematosus (MESH:D008178), fever (MESH:D005334), IgG4-related disease (MESH:D000077733), vomiting (MESH:D014839), lupus erythematosus panniculitis (MESH:D015435), autoimmune cholangitis (MESH:D002761), burns (MESH:D002056), systemic lupus erythematosus (MESH:D008180), fibrosis (MESH:D005355), granulomatous inflammation (MESH:D007249), fatty (MESH:D008067), trauma (MESH:D014947), pancreatic adenocarcinoma (MESH:D010190), pain (MESH:D010146), neoplasia (MESH:D009369), eosinophilia (MESH:D004802), pancreatitis (MESH:D010195), anorexia (MESH:D000855), abdominal pain (MESH:D015746), pyogranulomatous steatitis (MESH:D013231)
- **Chemicals:** ursodeoxycholic acid (MESH:D014580), steroid (MESH:D013256), lipid (MESH:D008055), calcium (MESH:D002118), 1,25-dihydroxyvitamin D (MESH:C097949), Prednisolone (MESH:D011239), ceroid (MESH:D002566), SNP (-), cyclosporine (MESH:D016572), 25-hydroxyvitamin D (MESH:C104450), polyunsaturated fatty acids (MESH:D005231), tocopherol (MESH:D024505), Famotidine (MESH:D015738), Silymarin (MESH:D012838), amoxicillin/clavulanic acid (MESH:D019980), Vitamin E (MESH:D014810), azathioprine (MESH:D001379)
- **Species:** Bartonella (genus) [taxon 773], Babesia gibsoni (species) [taxon 33632], Babesia canis (species) [taxon 5867], Homo sapiens (human, species) [taxon 9606], Felis catus (cat, species) [taxon 9685], Histoplasma capsulatum (species) [taxon 5037], Trypanosoma cruzi (species) [taxon 5693], Toxoplasma gondii (species) [taxon 5811], Blastomyces dermatitidis (species) [taxon 5039], Rickettsia rickettsii (species) [taxon 783], Brucella canis (species) [taxon 36855], Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12962883/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12962883/full.md

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Source: https://tomesphere.com/paper/PMC12962883