# Metastatic Prostate Cancer Presenting as Fatigue in an Older Adult **Authors:** Arianna R. Tidball, Elizabeth N. Harlow PMC · DOI: 10.1002/ccr3.72164 · Clinical Case Reports · 2026-03-05 ## TL;DR An older man with fatigue and urinary symptoms was found to have metastatic prostate cancer, emphasizing the importance of considering cancer in unexplained fatigue cases. ## Contribution This case report adds to the understanding of atypical presentations of metastatic prostate cancer in older adults. ## Key findings - Fatigue and urinary symptoms in an older man led to the discovery of metastatic prostate cancer. - The case underscores the importance of considering malignancy in the differential diagnosis of unexplained fatigue. ## Abstract Fatigue in older adults, though common and nonspecific, may signal serious disease. This report describes an older man whose complaint of fatigue, evaluated with urinary symptoms, revealed metastatic prostate cancer with diffuse bone involvement. This highlights the need to consider malignancy in the differential of unexplained fatigue. ## Linked entities - **Diseases:** metastatic prostate cancer (MONDO:0004956) ## Full-text entities - **Genes:** GGTLC5P (gamma-glutamyltransferase light chain 5 pseudogene) [NCBI Gene 653590] {aka GGT}, KLK3 (kallikrein related peptidase 3) [NCBI Gene 354] {aka APS, KLK2A1, PSA, hK3}, GGT1 (gamma-glutamyltransferase 1) [NCBI Gene 2678] {aka CD224, D22S672, D22S732, GGT, GGT 1, GGTD}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1} - **Diseases:** musculoskeletal pain (MESH:D059352), Fatigue (MESH:D005221), spinal cord compression (MESH:D013117), osteoarthritis (MESH:D010003), hyperlipidemia (MESH:D006949), Metastatic Prostate Cancer (MESH:D011471), inflammation (MESH:D007249), fractures (MESH:D050723), bone pain (MESH:D010146), cancer (MESH:D009369), prostatic adenocarcinoma (MESH:D000230), anxiety (MESH:D001007), depression (MESH:D003866), loss of taste (MESH:D000370), sleep apnea (MESH:D012891), urinary incontinence (MESH:D014549), Prostate (MESH:D011472), Bone Metastasis (MESH:D009362), hypertension (MESH:D006973), COVID-19 (MESH:D000086382), atrial fibrillation (MESH:D001281), cardiovascular and psychiatric comorbidities (MESH:D002318), weight loss (MESH:D015431), hypercalcemia (MESH:D006934) - **Chemicals:** oxybutynin (MESH:C005419), tamsulosin (MESH:D000077409), finasteride (MESH:D018120) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12962873/full.md ## References 13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12962873/full.md --- Source: https://tomesphere.com/paper/PMC12962873