# Acetazolamide Use in the Management of Refractory Acute Decompensated Heart Failure in the ICU

## TL;DR

This paper presents a case where acetazolamide helped manage severe heart failure when traditional treatments failed.

## Contribution

The paper introduces acetazolamide as a potential solution for diuretic resistance in acute heart failure.

## Key findings

- Acetazolamide led to significant diuresis and resolution of pulmonary edema in 72 hours.
- The patient showed clinical improvement after acetazolamide treatment.

## Abstract

Diuretic resistance is a major therapeutic challenge in acute decompensated heart failure (ADHF). Acetazolamide, a carbonic anhydrase inhibitor, has emerged as a potential adjunct to conventional loop diuretics, as demonstrated in the ADVOR trial. We present a 74-year-old woman with acute coronary syndrome complicated by cardiogenic shock and refractory pulmonary edema despite inotropic support and guideline-directed therapy. The patient received intravenous acetazolamide 500 mg daily for three days, resulting in marked diuresis and radiographic resolution of pulmonary edema within 72 hours. The patient improved clinically. This case supports the potential utility of acetazolamide as an adjunctive strategy for overcoming diuretic resistance in ADHF.