# Seizure as an Atypical Presentation of Myasthenia Gravis: A Rare but Critical Diagnostic Challenge

**Authors:** Huda Faisal, Chanchan, Karan Chaman Lal, Zahabia Adnan, Shamyl Zehra, MD. Faisal Ahmed

PMC · DOI: 10.1002/ccr3.72188 · Clinical Case Reports · 2026-03-05

## TL;DR

A rare case shows how myasthenia gravis can present with seizures, highlighting the need for careful diagnosis and treatment in overlapping neurological conditions.

## Contribution

Highlights a rare clinical overlap between myasthenia gravis and epilepsy, emphasizing the need for interdisciplinary management.

## Key findings

- A patient with myasthenia gravis and epilepsy presented with seizures and respiratory distress.
- The case underscores the importance of early detection and drug management in overlapping neuromuscular and neurological disorders.

## Abstract

A 27‐year‐old male patient with a known case of epilepsy and also recently diagnosed with myasthenia gravis presented with dysphagia, respiratory distress, and seizures. Despite timely intervention, he progressed into septic shock during a myasthenic crisis and succumbed to cardiopulmonary arrest. The underlying autoimmune nature of this condition shows a clinically significant and rare overlap between myasthenia gravis and epilepsy. This case emphasizes the importance of early detection and careful drug selection or management in neuromuscular and neurological disorders.

The unusual co‐occurrence of Myasthenia Gravis and epilepsy highlighted the importance of considering multiple possible diagnoses to ensure patient survival through insightful surveillance, interdisciplinary management, and careful drug choice. The identification of autoimmune overlap with neurological diseases not only improves diagnosis and treatment but also encourages researchers to investigate further.

## Linked entities

- **Diseases:** myasthenia gravis (MONDO:0009688), epilepsy (MONDO:0005027)

## Full-text entities

- **Genes:** IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, MUSK (muscle associated receptor tyrosine kinase) [NCBI Gene 4593] {aka CMS9, FADS}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** neurological impairment (MESH:D009422), autoimmune hepatitis (MESH:D019693), MG (MESH:D009157), rapid jerky movements (MESH:D020187), primary biliary cirrhosis (MESH:D008105), septic shock (MESH:D012772), neuromuscular and neurological disorders (MESH:D009468), sleep apnea (MESH:D012891), PNS (MESH:D010523), thymic abnormalities (MESH:D013953), infarction (MESH:D007238), cough (MESH:D003371), leukocytosis (MESH:D007964), paroxysmal nocturnal dyspnea (MESH:D004418), infection (MESH:D007239), chills (MESH:D023341), demyelinating (MESH:D003711), blood (MESH:D006402), intracranial abnormality (MESH:D001927), Connective tissue diseases (MESH:D003240), autoimmune Myasthenia Gravis (MESH:D020720), anemia (MESH:D000740), RA (MESH:D001172), Epilepsy (MESH:D004827), dysphagia (MESH:D003680), SLE (MESH:D008180), hypoxia (MESH:D000860), neurological ailment (MESH:D009461), sweats (MESH:D013543), genetic abnormalities (MESH:D030342), Seizure (MESH:D012640), fever (MESH:D005334), respiratory distress (MESH:D012128), chest pain (MESH:D002637), jaundice (MESH:D007565), clubbing (MESH:D003025), bleeding tendency (MESH:C536965), fatigue (MESH:D005221), acute respiratory failure (MESH:D012131), intracranial hemorrhage (MESH:D020300), autoimmune overlap syndromes (MESH:D000080445), autoimmune condition (MESH:D001327), neurological diseases (MESH:D020271), cardiopulmonary arrest (MESH:D006323), edema (MESH:D004487), CNS (MESH:D002493), substance abuse (MESH:D019966), SOB (MESH:D004417), muscle weakness (MESH:D018908), cyanosis (MESH:D003490), systemic illnesses (MESH:D012140), hypoventilation (MESH:D007040), myasthenic (MESH:D020294), inflammatory (MESH:D007249), loss of contractility (MESH:D016388), hyperglycemia (MESH:D006943)
- **Chemicals:** Levetiracetam (MESH:D000077287), Mestinon (MESH:D011729), steroids (MESH:D013256), fluoroquinolones (MESH:D024841), phenytoin (MESH:D010672), Ceftriaxone (MESH:D002443), macrolides (MESH:D018942), blood sugar (MESH:D001786), insulin (MESH:D007328), Solucortef (MESH:C007133), GABA (MESH:D005680), Glutamate (MESH:D018698), acetylcholine (MESH:D000109), Meropenem (MESH:D000077731), Dormicum (MESH:D008874), oxygen (MESH:D010100), Haloperidol (MESH:D006220)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12962840/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12962840/full.md

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Source: https://tomesphere.com/paper/PMC12962840