# Unexpected twist: large marginal branch occlusion of the left circumflex artery unveiled by immediate and pivotal cardiac magnetic resonance imaging in a 19-year-old with suspected myocarditis—a case report

**Authors:** Sebastian N Nagel, Wladimir N Tschishow, Ziyad Alomari, Carsten W Israel, Günther Wittenberg

PMC · DOI: 10.1093/ehjcr/ytag015 · 2026-01-22

## TL;DR

A 19-year-old with suspected myocarditis was found to have a heart artery blockage and endocarditis through MRI and tests.

## Contribution

Highlights the importance of early cardiac MRI in diagnosing rare causes of heart issues in young patients.

## Key findings

- Cardiac MRI identified lateral wall ischemia in a young patient with suspected myocarditis.
- Coronary angiography revealed a large marginal branch occlusion of the left circumflex artery.
- Pathological analysis confirmed septic embolism due to Streptococcus mitis endocarditis.

## Abstract

Myocarditis and myocardial infarction in young patients can present with overlapping symptoms, posing a diagnostic challenge. Advanced cardiac imaging, particularly cardiac magnetic resonance imaging (MRI), plays a pivotal role in distinguishing between these entities.

A 19-year-old male presented with a 5-week history of fever, general weakness, and new atypical chest pain, raising the suspicion of myocarditis. Immediate cardiac MRI revealed signs of lateral wall ischaemia. Coronary angiography confirmed an occlusion of a large marginal branch of the left circumflex artery. Pathological analysis of the retrieved thrombus indicated a septic embolism, and further investigations confirmed endocarditis due to Streptococcus mitis.

This case highlights the essential role of early cardiac MRI in guiding clinical decision-making, particularly in young patients with non-specific symptoms. Although rare, endocarditis-related septic embolism must be considered in the differential diagnosis of acute myocardial infarction in this population.

## Linked entities

- **Diseases:** myocarditis (MONDO:0004496), myocardial infarction (MONDO:0005068), endocarditis (MONDO:0005025)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** thromboembolic (MESH:D013923), coronary artery embolism (MESH:D003324), coronary embolism (MESH:D004617), depression (MESH:D003866), endocarditis (MESH:D004696), infarcts (MESH:D007238), perfusion (MESH:D001480), prolapse (MESH:D011391), septic (MESH:D001170), occlusion of (MESH:D001157), vegetation (MESH:D018458), ischaemic (MESH:D018917), branch occlusion of the (MESH:D012170), thrombus (MESH:D013927), coronary occlusion (MESH:D054059), artery (MESH:D012078), acute myocardial infarction (MESH:D009203), chest pain (MESH:D002637), myocardial injury (MESH:D009202), Myocarditis (MESH:D009205), mitral insufficiency (MESH:D008944), ischaemia (MESH:D007511), perfusion deficit (MESH:D009461), fever (MESH:D005334), inflammatory (MESH:D007249), borreliosis (MESH:D008193), weakness (MESH:D018908), heart valve defect (MESH:D006349)
- **Chemicals:** Gadolinium (MESH:D005682)
- **Species:** Streptococcus mitis (species) [taxon 28037], Homo sapiens (human, species) [taxon 9606]

## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12962232/full.md

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Source: https://tomesphere.com/paper/PMC12962232