Cationic nanoparticles-enabled mouthwash combats precancerous oral mucosal inflammation
Meijun Du, Kunyu Wang, Quanxin Ning, Fangman Chen, Renjie Yang, Suwan Ding, Shiming Zhang, Ziming Huo, Xiaochun Xie, Chuanxu Cheng, Bing Shi, Hanyao Huang, Dan Shao, Yi Li, Kam W Leong
TL;DR
A new mouthwash using cationic nanoparticles helps reduce precancerous oral inflammation linked to oral cancer development.
Contribution
A cationic nanoparticle-enabled mouthwash is developed to target and remove cell-free DNA, reducing inflammation in precancerous oral conditions.
Findings
Saliva cell-free DNA levels and TLR9 activation are linked to oral cancer progression.
Cationic nanoparticles in mouthwash reduced inflammation and tumor cell migration in vitro and in a mouse model.
The mouthwash inhibited TLR9 activation, alleviating precancerous oral mucosal inflammation.
Abstract
During the development of oral squamous cell carcinoma (OSCC), multiple danger signals can initiate chronic oral mucosal inflammation, which then gives rise to precancerous and cancerous lesions. Modulation of immune homeostasis is essential to intercept inflammation-driven OSCC. In this study, we aimed to identify key inflammatory danger signals involved in precancerous oral mucosal inflammation and to develop a locally applicable immunomodulatory strategy to prevent this precancerous inflammation. We first identified that saliva cell-free DNA (cfDNA) levels and cfDNA-induced TLR9 activation were linked to OSCC development and progression. Hypothesizing that removing cfDNA would be beneficial for OSCC prevention, we created a cationic nanoparticles-enabled mouthwash that regulates precancerous inflammation via removing negatively charged cfDNA. Both cationic nanoparticles and polymers…
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Taxonomy
TopicsOral health in cancer treatment · RNA Interference and Gene Delivery · Oral microbiology and periodontitis research