Occupational therapy improves functional recovery and reduces delirium in critically ill adults with and without stroke: a systematic review and meta-analysis

TL;DR

Occupational therapy in the ICU helps critically ill adults recover better and reduces delirium, especially for those with stroke.

Contribution

This study is the first systematic review and meta-analysis to evaluate the effectiveness of ICU-based occupational therapy in critically ill adults, including those with stroke.

Findings

Occupational therapy significantly improves activities of daily living and grip strength in ICU patients.

It reduces the incidence of delirium and shortens the duration of mechanical ventilation.

The benefits are particularly strong for stroke patients, who show improved ADL performance and lower delirium rates.

Abstract

Post-intensive care syndrome (PICS), encompassing physical, psychological, and cognitive impairments, significantly compromises recovery in critical illness survivors. Although occupational therapy (OT) may mitigate functional decline, its efficacy in the intensive care unit (ICU) remains inadequately established. This systematic review and meta-analysis evaluated the impact of OT on clinical outcomes in critically ill adults.

We searched PubMed, Embase, Web of Science, CINAHL, Cochrane Library, CNKI, Wanfang, and China Biomedical Literature Service System from inception to August 5, 2025 for randomized controlled trials (RCTs) assessing ICU-based OT. Primary outcomes included activities of daily living (ADL), delirium incidence, grip strength, and mechanical ventilation duration. Data were synthesized using RevMan 5.3, with continuous outcomes expressed as mean difference (MD) or standardized mean difference (SMD) and dichotomous outcomes as relative risk (RR), all with 95% confidence intervals (CIs). The certainty of evidence for each outcome was assessed using the GRADE approach.

Pooled analyses demonstrated that OT significantly enhanced ADL performance [SMD = 0.72, 95% CI (0.40, 1.05), p < 0.001], reduced the incidence of delirium [RR = 0.44, 95% CI (0.30, 0.63), p < 0.001], increased grip strength [MD = 3.90 kg, 95% CI (2.03, 5.76), p < 0.001], and shortened the duration of mechanical ventilation [SMD = −0.68, 95% CI (−0.99, −0.37), p < 0.001]. The certainty of evidence (GRADE) was low for ADL, and moderate for delirium, grip strength, and mechanical ventilation duration. Subgroup analysis of stroke patients further demonstrated that OT significantly improved ADL performance [SMD = 0.81, 95% CI (0.42, 1.20), p < 0.001] and reduced delirium incidence [RR = 0.39, 95% CI (0.21, 0.72), p = 0.003], suggesting a particularly beneficial effect in this vulnerable population.

This meta-analysis provides evidence that OT may enhance functional recovery, prevent delirium, and facilitate weaning in critically ill patients. However, the strength of the evidence is low to moderate, tempered by the limited number of trials, risk of bias, and observed heterogeneity. These findings underscore the need for further rigorous investigation to establish optimal protocols.

https://www.crd.york.ac.uk/PROSPERO/recorddashboard, Unique identifier: CRD42025312345.

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