Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma
Sicheng Bian, Jiangxia Cui, Xialin Zhang, Chongzhi Bai, Yanhong Tan, Zhuanghui Hao, Xingpeng Bu, Changxin Qu, Lili Sun, Leilei Lin, Qi Wang, Zhengrui Li, Xufeng Huang, Hengrui Liu, Ruo Wang, Yinghua Li, Hongwei Wang
TL;DR
This paper explains how immunoglobulin adhesion to RBC membranes increases ESR in multiple myeloma due to reduced sialic acid.
Contribution
The study identifies Band3 as a key site for immunoglobulin adhesion in multiple myeloma-related erythrocyte sedimentation.
Findings
Reduced sialic acid weakens RBC membrane negative charge barriers.
Immunoglobulin adhesion to Band3 peptides destabilizes RBC suspensions.
This adhesion leads to increased erythrocyte sedimentation rate in multiple myeloma.
Abstract
Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the loss of sialic acid coverage. Immunoglobulins in plasma adhere to RBC membrane Band3 extracellularly exposed peptides through intermolecular interactions. The reduction of sialic acid causes a weakening of the RBC membrane negative charge barrier and the adhesion of immunoglobulins further destabilises the suspension of RBCs, resulting in a rapid addition of ESR to multiple myeloma.
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Taxonomy
TopicsErythrocyte Function and Pathophysiology · Multiple Myeloma Research and Treatments · Glycosylation and Glycoproteins Research