Triethoxysilyl-Functionalized Polyethylenimine: Its Spontaneous Cross-Linking and Drug Retention
Erika Yoshihara, Ayaka Tomoda, Kana Morishita, Toshiyuki Takagi, Masayuki Sano, Kimio Sumaru
TL;DR
A new coating material was developed that can retain antimicrobial and antiviral agents, offering a stable solution for infection control in public and medical settings.
Contribution
The study introduces a novel cross-linking method for Si-PEI coatings that effectively retain water-soluble antimicrobial and antiviral agents.
Findings
Si-PEI coatings spontaneously cross-linked at room temperature after solvent evaporation.
The coatings retained copper(II) ions, sulfonamide antibiotics, and didecyldimethylammonium chloride, reducing leaching.
The coating effectively suppressed viral infectivity in real-world conditions.
Abstract
Effective antibacterial and antiviral coatings are expected to serve as effective infection control measures in medical and public environments. In this study, we investigated polyethylenimine functionalized with triethoxysilyl groups (Si-PEI) as a promising platform material to implement such coatings feasibly. Si-PEI, synthesized in ethanol in a one-pot reaction, was coated onto the material surface as a diluted solution and then spontaneously cross-linked after solvent evaporation at room temperature. The resulting water-resistant coating layer retained water-soluble antimicrobial components such as copper(II) ions and sulfonamide antibiotics within the cross-linked network, thereby moderately suppressing their leaching due to casual water exposure. Similar retention was also implemented for the antiviral agent didecyldimethylammonium chloride, and the coating layer demonstrated…
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Taxonomy
TopicsAntimicrobial agents and applications · Polymer Surface Interaction Studies · Graphene and Nanomaterials Applications