Graphene Oxide and Conductive Polymer–Enhanced Langmuir–Blodgett Biosensor for Sensitive Detection of Pyrocatechol
Felipe Merloto Marinho, Coral Salvo-Comino, Maria Luz Rodriguez-Mendez, José Roberto Siqueira Junior, Luciano Caseli
TL;DR
This paper introduces a new biosensor using graphene oxide and conductive polymers to detect pyrocatechol with high sensitivity and stability.
Contribution
The novel hybrid Langmuir-Blodgett film integrates graphene oxide, conductive polymer, and enzyme for enhanced biosensing performance.
Findings
Graphene oxide improves film compactness and enzyme-polymer-lipid stability.
The biosensor shows nearly 2-fold higher sensitivity and lower detection limits.
Synergy between components enhances redox cycling of pyrocatechol.
Abstract
In this work, we report a novel Langmuir–Blodgett (LB) biosensing platform for the detection of phenolic compounds, using Pyrocatechol as a model analyte. Although LB films have long been explored for polyphenol detection, the present study introduces an innovative hybrid architecture that integrates a lipid matrix (DMPA), a conductive polymer (P3HT), graphene oxide (GO), and laccase into a single, highly organized ultrathin film. This configuration simultaneously enhances film rigidity, reduces surface roughness, and modulates electron-transfer properties in a way not previously reported for LB-based enzymatic sensors. Comprehensive interfacial characterization (surface pressure–area isotherms, dilatational rheology, UV–Vis, AFM) reveals that GO plays a decisive role in promoting compact molecular packing and stabilizing the enzyme–polymer–lipid assembly. As a consequence, the…
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Taxonomy
TopicsElectrochemical sensors and biosensors · Conducting polymers and applications · Lipid Membrane Structure and Behavior