MycoMobilome: a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom

TL;DR

MycoMobilome is a new database of transposable element sequences in fungi, aiming to improve annotation accuracy and community collaboration.

Contribution

The novel contribution is a curated, non-redundant fungal transposable element database with naming conventions and metadata for traceability.

Findings

MycoMobilome includes 586,441 consensus sequences from 4309 fungal genomes.

The database includes metadata and naming conventions to guide further curation and evaluation.

Community contributions are encouraged to improve and expand the database.

Abstract

Transposable elements (TEs) are found in nearly all eukaryotic genomes. Despite significant advances in the sequencing of genomes, TE resources remain sparse, leading to a lack of traceability, reproducibility, and duplication of effort when annotating TEs. Here, we focus on the fungal kingdom and present MycoMobilome, a database of TE consensus sequences computationally curated using a set of 4309 genomes covering all major clades. The initial database contains 586 441 consensus sequences after filtering to remove putative host genes and low-quality consensus sequences. We provide a consistent naming convention to surface information on the confidence in the classification, including potential conflicting open reading frame functions, along with metadata to enable evaluation of TEs of interest and to determine whether further curation work is required on a case-by-case basis. Finally, we provide guidelines for community contributions and encourage researchers to deposit new or curated sequences, which will be incorporated into future MycoMobilome releases.

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