# Pulmonary Actinomycosis Mimicking Pulmonary Tuberculosis: A Diagnostic Challenge

**Authors:** Srikant K Malegaonkar

PMC · DOI: 10.7759/cureus.102871 · 2026-02-03

## TL;DR

This paper discusses a rare case where a lung infection was mistaken for tuberculosis, emphasizing the need for accurate diagnostic methods.

## Contribution

The paper presents a case highlighting the diagnostic challenge of distinguishing pulmonary actinomycosis from tuberculosis.

## Key findings

- Pulmonary actinomycosis can closely resemble tuberculosis in symptoms and imaging.
- Histopathological examination and anaerobic culture are crucial for accurate diagnosis when tuberculosis treatment fails.

## Abstract

Pulmonary actinomycosis is a rare chronic infection that can closely mimic pulmonary tuberculosis (PTB) in both clinical presentation and radiological appearance, particularly in tuberculosis-endemic regions. Delayed or missed diagnosis may result in prolonged inappropriate therapy and disease progression.

We report a case of pulmonary actinomycosis in a diabetic patient initially treated empirically for pulmonary tuberculosis, highlighting the importance of histopathological examination and anaerobic culture in patients with poor response to anti-tubercular therapy.

## Linked entities

- **Diseases:** pulmonary tuberculosis (MONDO:0006052), diabetes (MONDO:0005015)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** empyema (MESH:D004653), malignancy (MESH:D009369), lung consolidation (MESH:D008171), diabetes (MESH:D003920), opacity (MESH:D003318), pneumonia (MESH:D011014), fever (MESH:D005334), granulomatous infection (MESH:D007239), PTB (MESH:D014397), Pulmonary Actinomycosis (MESH:D000196), weight loss (MESH:D015431), cough (MESH:D003371), leukocytosis (MESH:D007964), type 2 diabetes mellitus (MESH:D003924), granulomas (MESH:D006099), tuberculosis (MESH:D014376), tubercular (MESH:D014390), fistula (MESH:D005402), necrosis (MESH:D009336)
- **Chemicals:** doxycycline (MESH:D004318), hypertonic saline (MESH:D012965), amoxicillin-clavulanate (MESH:D019980), silver nitrate (MESH:D012835), clindamycin (MESH:D002981), meropenem (MESH:D000077731), amoxicillin (MESH:D000658), ATT (-), sulphur (MESH:D013455), creatinine (MESH:D003404), glucose (MESH:D005947)
- **Species:** Actinomyces israelii (species) [taxon 1659], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12961417/full.md

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Source: https://tomesphere.com/paper/PMC12961417