# SGLT2 inhibitors and bone health in CKD

**Authors:** Mathias Haarhaus

PMC · DOI: 10.1093/ckj/sfag021 · 2026-02-11

## Full-text entities

- **Genes:** KL (klotho) [NCBI Gene 9365] {aka HFTC3, KLA}, CYP27A1 (cytochrome P450 family 27 subfamily A member 1) [NCBI Gene 1593] {aka CP27, CTX, CYP27}, SLC5A2 (solute carrier family 5 member 2) [NCBI Gene 6524] {aka SGLT2}, ALPP (alkaline phosphatase, placental) [NCBI Gene 250] {aka ALP, PALP, PLAP, PLAP-1}, ACP5 (acid phosphatase 5, tartrate resistant) [NCBI Gene 54] {aka HPAP, TRACP5a, TRACP5b, TRAP, TRAcP, TrATPase}, FGF23 (fibroblast growth factor 23) [NCBI Gene 8074] {aka ADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTC}, PTH (parathyroid hormone) [NCBI Gene 5741] {aka FIH1, PTH1}
- **Diseases:** CKD (MESH:D012080), Cardiovascular disease (MESH:D002318), bone abnormalities (MESH:D001847), dehydration (MESH:D003681), urinary tract infections (MESH:D014552), osteoporosis (MESH:D010024), HEALTH (OMIM:603663), phosphaturia (MESH:D007015), vascular calcification (MESH:D061205), premature death (MESH:D003643), MECHANISM (MESH:D041781), mineral disturbances (MESH:C537337), diabetes mellitus type 2 (MESH:D003924), Kidney Disease (MESH:D007674), diabetic ketoacidosis (MESH:D016883), diabetic (MESH:D003920), CKD (MESH:D051436), DM (MESH:D009223), liver disease (MESH:D008107), Fracture (MESH:D050723), proteinuria (MESH:D011507), BMD (MESH:D001851), falls (MESH:C537863)
- **Chemicals:** dapagliflozin (MESH:C529054), 1,25 (OH)2 vitamin D. (-), sodium (MESH:D012964), glucose (MESH:D005947), calcium (MESH:D002118), vitamin D (MESH:D014807), phosphate (MESH:D010710), canagliflozin (MESH:D000068896)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12961378