# Clinical and Surgical Approach to Oral Papilloma in the Soft Palate: A Case Report

**Authors:** María Victoria Espinoza-Salcedo, Edward Henry Miranda-Gutierrez, Jhair Alexander Leon-Rodriguez, Jorge Luis Huarcaya-López, Otto Jhonny Ajalcriña-Hernández, Alexander Roger Espinoza-Salcedo, Jhohan Ismael Leon-Rodriguez

PMC · DOI: 10.1155/crid/8847872 · 2026-03-04

## TL;DR

This case report describes the diagnosis and surgical treatment of a benign oral papilloma in a patient's soft palate.

## Contribution

The paper presents a clinical case highlighting the importance of early diagnosis and surgical management of oral papilloma.

## Key findings

- Surgical excision was effective for treating a benign papilloma in the soft palate.
- Histopathological analysis confirmed the diagnosis of oral papilloma with epithelial hyperplasia and koilocytes.
- Early diagnosis helps differentiate benign lesions from malignant oral pathologies.

## Abstract

Oral papilloma is a benign lesion caused by the human papillomavirus (HPV), characterized by an exophytic, vegetative, verrucous, or papular growth in the oral mucosa. This type of lesion can be located in various areas of the oral cavity and represents one of the main clinical manifestations associated with HPV infections. Early diagnosis is crucial to rule out malignant conditions and ensure appropriate treatment.

A 59‐year‐old male patient attended the Odontoestomatology Department at the Regional Teaching Hospital of Trujillo due to an asymptomatic growth in the right soft palate with a 2‐year history. Clinical examination revealed an exophytic lesion approximately 5 mm in diameter, with normal coloration, rough texture, and a pedunculated base. An excisional biopsy of the lesion was performed, and histopathological analysis confirmed the presence of oral papilloma with epithelial hyperplasia and koilocytes, confirming the benign nature of the lesion.

Surgical excision proved to be an effective and definitive treatment for oral squamous papilloma of the soft palate. Early recognition and appropriate management are crucial to differentiate benign papillomatous lesions from potentially malignant oral pathologies and to prevent unnecessary complications.

## Full-text entities

- **Diseases:** oral verruca vulgaris (MESH:D014860), epithelial hyperplasia (MESH:D017573), hyperkeratosis (MESH:D017488), oropharyngeal cancers (MESH:D009959), verrucous carcinoma (MESH:D018289), benign (MESH:D009369), Infection (MESH:D007239), palate (MESH:D002972), oral (MESH:D020820), lesion on the (MESH:D009059), epithelial dysplasia (MESH:C567703), Papilloma (MESH:D010212), condyloma (MESH:D062688), squamous cell carcinoma (MESH:D002294), oropharyngeal squamous cell carcinoma (MESH:D000077195), papillomatous lesions (MESH:D058066), parakeratosis (MESH:D010241), leukoplakia (MESH:D007971), HPV infection (MESH:D030361), acanthosis (MESH:D000052)
- **Chemicals:** lidocaine (MESH:D008012), epinephrine (MESH:D004837), formalin (MESH:D005557), alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human papillomavirus (species) [taxon 10566]
- **Mutations:** A 30G

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12961225/full.md

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Source: https://tomesphere.com/paper/PMC12961225