# Hypertrophic Pachymeningitis Possibly Secondary to Otitis Media

**Authors:** Bo Wang, Guoyong Qin, Jiafang Wang, Kebin Zeng

PMC · DOI: 10.1155/carm/4541532 · 2026-03-04

## TL;DR

A 46-year-old woman with hearing loss and headache was found to have hypertrophic pachymeningitis possibly linked to otitis media, which improved with corticosteroid treatment.

## Contribution

This case highlights a potential link between otitis media and hypertrophic pachymeningitis, suggesting postinfectious immune mechanisms.

## Key findings

- The patient's symptoms and imaging findings indicated progressive involvement of the tentorium cerebelli.
- High-dose corticosteroid therapy led to significant symptom relief, implying an immune–inflammatory cause.
- The case suggests a possible secondary origin of hypertrophic pachymeningitis from otitis media.

## Abstract

This study describes a 46‐year‐old female patient who initially presented with hearing impairment and subsequently developed a headache as the predominant symptom, accompanied by the involvement of multiple cranial nerves, including the optic, vestibulocochlear, and trigeminal nerves. Cerebrospinal fluid pressure progressively increased, and imaging demonstrated progression from unilateral to bilateral involvement of the tentorium cerebelli. Clinically, the patient’s hypertrophic pachymeningitis was considered associated with otitis media. After receiving high‐dose corticosteroid pulse therapy, the patient experienced marked relief of the headache and associated symptoms, which was presumed to be related to postinfectious immune–inflammatory mechanisms.

## Linked entities

- **Diseases:** otitis media (MONDO:0005441)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** syphilis (MESH:D013587), headache (MESH:D006261), fibrotic inflammation (MESH:D007249), artery ophthalmic segment aneurysm (MESH:D002532), optic disc edema (MESH:D010211), occipital pain (MESH:D010146), tumor (MESH:D009369), otitis media associated with antineutrophil cytoplasmic antibody-associated vasculitis (MESH:D056648), aneurysm (MESH:D000783), deafness (MESH:D003638), tinnitus (MESH:D014012), hemorrhage (MESH:D006470), urticaria (MESH:D014581), autoimmune disorders (MESH:D001327), vertigo (MESH:D014717), hearing impairment (MESH:D034381), neurological disorder (MESH:D009461), vomiting (MESH:D014839), Otitis Media (MESH:D010033), metastasis (MESH:D009362), thrombosis (MESH:D013927), internal carotid artery aneurysm (MESH:D002340), subarachnoid hemorrhage (MESH:D013345), diplopia (MESH:D004172), infection (MESH:D007239), pulmonary tuberculosis (MESH:D014397), hypesthesia (MESH:D006987), hypoplasia of the left transverse sinus (MESH:D020227), HIV (MESH:D015658), HCP (MESH:D014390), chronic (MESH:D002908)
- **Chemicals:** O (MESH:D010100), methylprednisolone (MESH:D008775), chloride (MESH:D002712), intracranial (-), prednisone (MESH:D011241), mannitol (MESH:D008353)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12960775/full.md

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Source: https://tomesphere.com/paper/PMC12960775