DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk

Yufan Zhou; Peiwen Yang; Hanxun He; Hao Liu; Ping Ye; Jiahong Xia

PMC · DOI:10.3389/fcvm.2026.1660204·February 3, 2026

DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk

Yufan Zhou, Peiwen Yang, Hanxun He, Hao Liu, Ping Ye, Jiahong Xia

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TL;DR

The DAB2IP gene plays a key role in linking cardiovascular diseases and brain disorders through multiple biological pathways.

Contribution

This paper highlights DAB2IP as a unifying factor in cardiovascular and neurological pathogenesis and crosstalk.

Findings

01

DAB2IP regulates inflammation, apoptosis, and plaque angiogenesis in atherosclerosis via multiple signaling pathways.

02

DAB2IP is genetically linked to coronary artery disease, aortic aneurysm, and aortic dissection.

03

DAB2IP influences brain processes like neuron migration and blood-brain barrier integrity in Alzheimer's disease models.

Abstract

Cardiovascular diseases and brain disorders collectively represent a major global health burden. Not only do they frequently occur as comorbidities, but their pathological mechanisms are also intricately linked through a complex network of cardiovascular-brain crosstalk. Cardiovascular diseases (CVDs) and neurological disorders together impose high global health burdens. The DAB2IP gene, initially characterized as a tumor suppressor, serves as a multifunctional regulator and performs roles in both the cardiovascular and neurological systems. In atherosclerosis (AS), DAB2IP suppresses the inflammation and apoptosis of endothelial cells (ECs) through the TNF signaling pathways, inhibits phenotypic switching of vascular smooth muscle cells (VSMCs) via the JAK-STAT and PI3K-Akt axes, and attenuates plaque angiogenesis via VEGF-related pathways. It is genetically associated with coronary…

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes61

Proteins24

Species6

Saccharomyces cerevisiae(baker's yeast · species)Mus musculus(house mouse · species)Nicotiana tabacum(American tobacco · species)Homo sapiens(human · species)Rattus norvegicus(brown rat · species)Bos taurus(bovine · species)

Chemicals15

adrenaline PIP2 oxygen fat nitric oxide testosterone IP3 phosphatidylinositol 4-phosphate amyloid-beta1-42 glucose ROS calcium dehydroepiandrosterone lipid carbon dioxide

Diseases64

atherosclerosis coronary artery disease aortic aneurysm Alzheimer's disease BBB AA neuroinflammation Alzheimer's impairment of arteriosclerosis aneurysms endothelial dysfunction diabetic AD rupture large vessel disease cancers pain coronary lesions premature ovarian failure intracranial aneurysm neurodegenerative diseases Disease HL inflammation fibrosis hyperlipidemia aortic diseases prostate cancer cardiogenic stroke cardiocerebrovascular disorders neurofibrillary tangles Hypoxia neurological disorders MDD small vessel disease metabolic disorders AAAs cardiomyopathies Stroke Stanford type A noncommunicable disease cerebral amyloid angiopathy postoperative organ dysfunction hypoxic obese SVC endothelial injury cerebrovascular disease insulin resistance myocardial infarction CVDs aneurysm dilation ischemic stroke CS vascular dementia brain disorders hypertension deaths post-menopausal myocardial infarction AS AAA cardio-cerebral comorbidities restenosis

Mutations9

rs7025486G>ars885150 rs35061590 rs13290547 rs10818576 rs587936G to Ars3798220

Figures4

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Taxonomy

TopicsBarrier Structure and Function Studies · Nuclear Receptors and Signaling · Cholesterol and Lipid Metabolism