# Case report: A systematic approach for the forensic evaluation of child abuse: lessons from a complex case

**Authors:** Pierpaolo Di Lorenzo, Emanuele Capasso, Anita Sammarco, Maria Pieri, Claudia Casella

PMC · DOI: 10.3389/fpsyt.2026.1631508 · Frontiers in Psychiatry · 2026-02-03

## TL;DR

This paper presents a complex case of child abuse and neglect, emphasizing the importance of a systematic forensic evaluation to distinguish intentional injury from accidental ones.

## Contribution

The paper provides a detailed case study illustrating the application of international protocols in diagnosing child abuse amidst complex medical conditions.

## Key findings

- A systematic diagnostic work-up led to a definitive diagnosis of child abuse and neglect.
- The case highlights the challenges of evaluating abuse in children with underlying medical conditions.
- The approach serves as an educational resource for healthcare professionals.

## Abstract

Child abuse (CA) remains a significant public health concern, where distinguishing between accidental and intentional injury is particularly difficult in complex cases involving underlying medical conditions. We present a disturbing case study of severe abuse and neglect to illustrate the necessity of a systematic and evidence-based approach to forensic evaluation. The case featured a complex clinical picture: multiple bone fractures in a child with Infantile Epileptic Spasms Syndrome (West Syndrome), under treatment with valproic acid, and evidence of cocaine exposure. A systematic diagnostic work-up, structured according to authoritative international protocols, was conducted, including detailed medical history, physical examination, imaging, toxicological, and genetic analyses. Despite these compounding challenges, a careful clinical evaluation and critical review of international guidelines led to a definitive diagnosis of child abuse and neglect. This work represents a valuable educational resource for healthcare professionals and underscores the significance of implementing systematic protocols for assessing child maltreatment.

## Linked entities

- **Chemicals:** valproic acid (PubChem CID 3121), cocaine (PubChem CID 2826)
- **Diseases:** Infantile Epileptic Spasms Syndrome (MONDO:0018097), West Syndrome (MONDO:0018097)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** pathological fractures (MESH:D005598), systemic (MESH:D015619), underweight (MESH:D013851), skeletal deformities (MESH:D009140), palmar laxity (MESH:D007593), bruises (MESH:D003288), abdominal traumas (MESH:D000007), Infantile (OMIM:271245), femoral fracture (MESH:D005264), sepsis (MESH:D018805), developmental delay (MESH:D002658), myoclonic encephalopathy (MESH:D004831), malnourished (MESH:D044342), death (MESH:D003643), brain damage (MESH:D001925), psychomotor arrest (MESH:D011596), muscular hypotonia (MESH:D009123), arcuate deformity (MESH:D012607), Epileptic Spasms Syndrome (MESH:D013035), Anemia (MESH:D000740), fractures of the humerus (MESH:D006810), epileptic (MESH:D004827), bone disease (MESH:D001847), dehydration (MESH:D003681), sexual abuse (MESH:D000082002), Child maltreatment (MESH:C562515), dental lesions (MESH:D009057), dermatitis (MESH:D003872), neglect (MESH:D058069), Vitamin D (MESH:D014808), multiple fractures (MESH:D000069076), NAI (MESH:D000081084), metabolic bone disease (MESH:D001851), West Syndrome (MESH:D013036), bleeding (MESH:D006470), alopecia (MESH:D000505), lesions (MESH:D009059), tibia (MESH:C535563), congenital bone fragility conditions (MESH:C536063), burns (MESH:D002056), genetic fragility (MESH:D005600), CA (MESH:C535569), Fractures (MESH:D050723), head trauma (MESH:D006259), Skin lesions (MESH:D012871), PD (MESH:D010300), inflammatory (MESH:D007249), Injuries (MESH:D014947), hematomas (MESH:D006406), ulnar deviation (MESH:D010262), Femurs (MESH:D000092524), intracranial lesions (MESH:D020765), mental disorders (MESH:D001523), abuse (MESH:D019966), retinal hemorrhages (MESH:D012166), muscle weakness (MESH:D018908), dysmorphic (MESH:D057215)
- **Chemicals:** benzoylecgonine (MESH:C005618), Anti (-), sodium valproate (MESH:D014635), cocaine (MESH:D003042), vitamin D (MESH:D014807)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12960626/full.md

## References

59 references — full list in the complete paper: https://tomesphere.com/paper/PMC12960626/full.md

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Source: https://tomesphere.com/paper/PMC12960626