# Can artificial intelligence in orthopantomography advance dental diagnostics through automated image analysis?

**Authors:** Dan Adrian Lutescu, Claudiu Constantin Manole, Ana Maria Cristina Țâncu, Radu Ilinca, Reinhard Chun Wang Chau, Szabolcs Felszeghy, Andreea Cristiana Didilescu

PMC · DOI: 10.3389/fradi.2026.1701356 · Frontiers in Radiology · 2026-02-19

## TL;DR

This paper reviews how AI is improving dental diagnostics through automated analysis of orthopantomograms, highlighting both progress and challenges in implementation.

## Contribution

The paper uniquely integrates AI diagnostic advancements with the evolving regulatory and ethical landscape in dental radiology.

## Key findings

- AI models achieve high accuracy in tooth identification and segmentation in orthopantomograms.
- Commercial AI solutions show variable performance in diagnosing complex dental conditions.
- Regulatory and ethical frameworks are being developed to support safe AI integration in dental care.

## Abstract

Artificial Intelligence (AI) is rapidly transforming dental education and clinical practice, as deep learning—especially convolutional neural networks—brings unprecedented accuracy to interpreting orthopantomograms (OPGs). This review illuminates the cutting-edge frontiers of AI-driven dental imaging, tracing how recent breakthroughs are transforming the detection, classification, and segmentation of complex dental anatomy and pathology. Notably, state-of-the-art AI models have reached remarkably high accuracy in tooth identification, while commercial solutions demonstrate promising—though variable—performance in diagnosing complex conditions, such as the adequacy of endodontic procedures. Yet, bringing AI into routine dental care remains fraught with obstacles — demanding vast annotated datasets, coping with population variability, and confronting persistent medicolegal and trust concerns. Growing collaborations between regulators and professional bodies in the United States and European Union are now shaping ethical and legal frameworks to guide its safe use. This narrative review goes beyond summarizing technological progress in AI-driven dental radiology — it uniquely integrates diagnostic breakthroughs with the rapidly evolving regulatory and ethical landscape. By bridging innovation with implementation, it offers educators, practitioners, and learners a forward-looking roadmap that positions AI not as a distant promise, but as a transformative force already reshaping the future of dental diagnostics and training.

## Full-text entities

- **Genes:** BTF3P11 (basic transcription factor 3 pseudogene 11) [NCBI Gene 690] {aka BRF3L1, BTF3L1, HUMBTFB, OCIF, OPG, TNFRSF11B}
- **Diseases:** fractures (MESH:D050723), pancreatic tumors (MESH:D010190), gingival inflammation (MESH:D007249), molar (MESH:D006828), osteoporotic (MESH:D058866), AD (MESH:D000544), temporal lobe epilepsy (MESH:D004833), calcification of (MESH:D002114), AI (MESH:C538142), PALs (MESH:D010483), attachment loss (MESH:D017622), damage (MESH:D020263), colorectal cancer (MESH:D015179), caries (MESH:D003731), dental anomalies (OMIM:614188), alveolar bone loss (MESH:D016301), gingivitis (MESH:D005891), bone lesions (MESH:D001847), osteoporosis (MESH:D010024), retinal nerve (MESH:D012173), endodontic lesions (MESH:D011671), periodontal diseases (MESH:D010510)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12960596/full.md

## References

61 references — full list in the complete paper: https://tomesphere.com/paper/PMC12960596/full.md

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Source: https://tomesphere.com/paper/PMC12960596