# Editorial: Advances in DYRK1A syndrome: underlying mechanisms, disease models, and novel therapeutic approaches

**Authors:** Oliver K. Glass, Amelie Piton, Anna Pfalzer

PMC · DOI: 10.3389/fnins.2026.1803346 · Frontiers in Neuroscience · 2026-02-19

## Full-text entities

- **Genes:** GSPT1 (G1 to S phase transition 1) [NCBI Gene 2935] {aka 551G9.2, ETF3A, GST1, eRF3a}, DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) [NCBI Gene 1859] {aka DYRK, DYRK1, HP86, MNB, MNBH, MRD7}, Akt1 (Akt serine/threonine kinase 1) [NCBI Gene 11651] {aka Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac}, ATF3 (activating transcription factor 3) [NCBI Gene 467], MAPK1 (mitogen-activated protein kinase 1) [NCBI Gene 5594] {aka ERK, ERK-2, ERK2, ERT1, MAPK2, NS13}, RNF114 (ring finger protein 114) [NCBI Gene 55905] {aka PSORS12, ZNF313}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}, Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) [NCBI Gene 18708] {aka PI3K, p50alpha, p55alpha, p85alpha}, Ngf (nerve growth factor) [NCBI Gene 18049] {aka Ngfb, beta-NGF}, Dyrk1a (dual-specificity tyrosine phosphorylation regulated kinase 1a) [NCBI Gene 13548] {aka 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Gm10783, Mnbh}, Rest (RE1-silencing transcription factor) [NCBI Gene 19712] {aka 2610008J04Rik, NRSF, REST4}, DCAF7 (DDB1 and CUL4 associated factor 7) [NCBI Gene 10238] {aka AN11, HAN11, SWAN-1, WDR68}, Mtor (mechanistic target of rapamycin kinase) [NCBI Gene 56717] {aka 2610315D21Rik, FRAP, FRAP2, Frap1, RAFT1, RAPT1}, PTBP2 (polypyrimidine tract binding protein 2) [NCBI Gene 58155] {aka PTBLP, brPTB, nPTB}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}
- **Diseases:** NDD (MESH:D002658), abnormal dentition (MESH:C566644), anxious/stereotypical behaviors (MESH:D019956), skeletal anomalies (MESH:C535534), trichothiodystrophy (MESH:D054463), NER disorders (MESH:D000072662), feeding (MESH:D001068), ADHD (MESH:D001289), DYRK1A Syndrome (MESH:C566928), intellectual disability (MESH:D008607), ataxic (MESH:D001039), skeletal deficits (MESH:D009461), craniofacial dysmorphology (MESH:D005157), deep-set eyes (MESH:D020920), CS (MESH:D003057), language impairment (MESH:D007806), dental abnormalities (MESH:D014071), craniofacial dysmorphisms (MESH:C537512), microcephaly (MESH:D008831), Down syndrome (MESH:D004314), febrile seizures (MESH:D003294), anxious or autistic behaviors (MESH:D001321), fetal growth restriction (MESH:D005317), autism spectrum syndrome (MESH:D000067877), DYRK1A syndrome (MESH:D013577), impaired speech development (OMIM:245570), short stature (MESH:D006130)
- **Chemicals:** calcium (MESH:D002118), glutamate (MESH:D018698)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Mutations:** c.1024G > T, c.524del

## Full text

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## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12960572/full.md

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Source: https://tomesphere.com/paper/PMC12960572