# Hemodynamic effects of red blood cell transfusion in patients with hemato-oncologic diseases

## TL;DR

This study shows that red blood cell transfusions in cancer patients can improve heart function and blood pressure, but more research is needed on long-term effects.

## Contribution

The study introduces a novel non-invasive method to assess acute hemodynamic changes after RBC transfusion in hemato-oncologic patients.

## Key findings

- RBC transfusion significantly increased central and peripheral blood pressures and reduced heart rate.
- There were non-significant trends toward improved blood rheology and vascular function.
- Immediate hemodynamic effects appeared beneficial, but long-term outcomes remain unclear.

## Abstract

The hemodynamic effects of red blood cell (RBC) transfusion in patients with hemato-oncologic diseases can be adverse. We measured acute hemodynamic changes with a novel non-invasive monitoring device.

Twenty-six patients (9 female, 17 male; median age 73) with hematological malignancies or solid tumors were included. Peripheral and central hemodynamics were assessed before and after RBC transfusion using the VascAssist2.0 device.

Baseline hemoglobin was 7.8 g/dL (range 6.2–8.7). Post-transfusion, significant hemodynamic changes were observed: heart rate decreased from 81 to 74 bpm (p < 0.0001). Both brachial and aortic systolic and diastolic blood pressures increased significantly (brachial SBP: 123–128 mmHg, p = 0.001; aortic SBP: 101–109 mmHg, p = 0.0003; brachial DBP: 62–64 mmHg, p = 0.01; aortic DBP: 61–64 mmHg, p = 0.02). The augmentation index adjusted to 75 bpm (AIx75) also rose significantly (11–18%, p = 0.003). There were non-significant trends toward decreased aortic pulse wave velocity (p = 0.09) and increased estimated blood viscosity (p = 0.053), indicating possible beneficial rheological effects.

RBC transfusion in patients with hemato-oncologic diseases resulted in significant increases in central and peripheral blood pressures and a reduction in heart rate in our pilot study. Trends toward improved blood rheology and vascular function were observed, though not statistically significant. While these immediate hemodynamic effects appear beneficial, further research is needed to determine long-term outcomes, especially for patients requiring frequent transfusions.

Infographic illustrates effects of anemia and red blood cell transfusion. Anemia is shown with a sad person, low hemoglobin, increased heart rate, decreased blood pressure, and reduced viscosity. After transfusion, a happy person appears with increased blood pressure, higher viscosity, increased augmentation index, decreased pulse wave velocity trend, and improved heart function.