# From genes to networks: neurobiological bases of neurodiversity across common developmental disorders

## TL;DR

This review explores the shared and distinct biological mechanisms underlying various neurodevelopmental disorders, highlighting common genetic and molecular pathways.

## Contribution

The paper introduces a systems-based, multi-level approach to understanding the biological basis of neurodiversity across disorders.

## Key findings

- Shared genes in NDDs are involved in synaptic function, chromatin remodeling, and immune pathways.
- Disrupted pathways like mTOR and Wnt/Beta-Catenin are common across multiple neurodevelopmental disorders.
- Prenatal and postnatal disruptions in neurogenesis and synaptic pruning contribute to NDDs.

## Abstract

Neurodiversity is a category for many NDDs, ranging from ASD to OCD. The Clinical Symptoms associated with NDDs may differ, but have many common features. Hence, there are many biological similarities between the various Neurodevelopmental Disorders. It has been assumed that one cause of these commonalities is due to shared Etiologies. This review provides information about Genes (Genetics), Proteins (Molecular), and Biology. Together, they provide evidence for common mechanisms (convergent) and Different mechanisms (divergent) across all Neurodevelopmental Disorders. These Types often share Polygenic Genes with Rare and Common Variants. The Shared Genes are commonly involved in the regulation of Synaptic Function, Chromatin Remodeling, and Immune Pathways. In addition, NDDs often have disrupted pathways associated with mTOR, Wnt/Beta-Catenin, and Immune Pathways. We also consider the Impact of Spatial and Temporal Gene Expression on NDD development across different stages (from Prenatal Development to Postnatal Development). We also discuss the impact of disruption during Prenatal and Postnatal Maturation of the Brain, including alterations in the processes of Neurogenesis, Synaptic Pruning, and Neural Circuit Integration. Based on these findings, we present a systems-based, multi-level approach to help understand the biological basis of neurodiversity, along with future research directions on Therapeutic Strategies across Diagnostic Groups, Developmentally Informed Interventions, and the Development of Inclusive Clinical and Societal Practices.