# Commentary: Novel mtDNA methylation-associated prognostic signatures in colorectal cancer

**Authors:** Xin Jiang, Xu Zhang, Maonan Wang

PMC · DOI: 10.3389/fonc.2026.1780394 · Frontiers in Oncology · 2026-02-19

## Full-text entities

- **Genes:** FCN3 (ficolin 3) [NCBI Gene 8547] {aka FCNH, HAKA1}, KDR (kinase insert domain receptor) [NCBI Gene 3791] {aka CD309, FLK1, VEGFR, VEGFR2}, PTK2 (protein tyrosine kinase 2) [NCBI Gene 5747] {aka FADK, FADK 1, FAK, FAK1, FRNK, PPP1R71}, EPHB2 (EPH receptor B2) [NCBI Gene 2048] {aka BDPLT22, CAPB, DRT, EK5, EPHT3, ERK}, TINAG (tubulointerstitial nephritis antigen) [NCBI Gene 27283] {aka TIN-AG}, CGAS (cyclic GMP-AMP synthase) [NCBI Gene 115004] {aka C6orf150, D4, MB21D1, h-cGAS}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, PDGFRB (platelet derived growth factor receptor beta) [NCBI Gene 5159] {aka CD140B, IBGC4, IMF1, JTK12, KOGS, OPDKD}, ZHX2 (zinc fingers and homeoboxes 2) [NCBI Gene 22882] {aka AFR1, RAF}, SLURP1 (secreted LY6/PLAUR domain containing 1) [NCBI Gene 57152] {aka ANUP, ARS, ArsB, LY6-MT, LY6LS, MDM}, RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) [NCBI Gene 5894] {aka CMD1NN, CRAF, NS5, Raf-1, c-Raf}, MMRN1 (multimerin 1) [NCBI Gene 22915] {aka ECM, EMILIN4, GPIa*, MMRN}, CSF1R (colony stimulating factor 1 receptor) [NCBI Gene 1436] {aka BANDDOS, C-FMS, CD115, CSF-1R, CSFR, FIM2}, STING1 (stimulator of interferon response cGAMP interactor 1) [NCBI Gene 340061] {aka ERIS, MITA, MPYS, NET23, SAVI, STING}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}, TEK (TEK receptor tyrosine kinase) [NCBI Gene 7010] {aka CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1}
- **Diseases:** mitochondrial dysfunction (MESH:D028361), CRC (MESH:D015179), metastasis (MESH:D009362), toxicity (MESH:D064420), cancer (MESH:D009369), cold (MESH:D000067390), carcinogenesis (MESH:D063646), hypoxia (MESH:D000860)
- **Chemicals:** Regorafenib (MESH:C559147), urea (MESH:D014508), sorafenib (MESH:D000077157), bisulfite (MESH:C042345)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12960107/full.md

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Source: https://tomesphere.com/paper/PMC12960107