# Single‐cell multi‐omics analysis of the tumour microenvironment for colorectal cancer liver metastasis

**Authors:** Jiao Guan, Mingwei Guo, Min Hu, Shilin Wu, Jin Qiu, Xinran Ma, Yingying Guo, Haibing Chen, Zunqiang Zhou

PMC · DOI: 10.1002/ctm2.70626 · Clinical and Translational Medicine · 2026-03-04

## Full-text entities

- **Genes:** NR4A2 (nuclear receptor subfamily 4 group A member 2) [NCBI Gene 4929] {aka HZF-3, IDLDP, NOT, NURR1, RNR1, TINUR}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, TRB (T cell receptor beta locus) [NCBI Gene 6957] {aka TCRB, TRB@}, Cd3d (CD3 antigen, delta polypeptide) [NCBI Gene 12500] {aka T3d}, Irf8 (interferon regulatory factor 8) [NCBI Gene 15900] {aka ICSBP, IRF-8, Icsbp1, Myls}, TRA (T cell receptor alpha locus) [NCBI Gene 6955] {aka IMD7, TCRA, TRA@}, IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)) [NCBI Gene 3501], SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, CTLA4 (cytotoxic T-lymphocyte associated protein 4) [NCBI Gene 1493] {aka ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4}, COL4A2 (collagen type IV alpha 2 chain) [NCBI Gene 1284] {aka BSVD2, BSVD2A, BSVD2B, ICH, POREN2}, TOX (thymocyte selection associated high mobility group box) [NCBI Gene 9760] {aka TOX1}, Hnf1b (HNF1 homeobox B) [NCBI Gene 21410] {aka HNF-1-beta, HNF-1B, HNF-1Beta, Hnf1beta, LFB3, Tcf-2}, Lyz1 (lysozyme 1) [NCBI Gene 17110] {aka Lyz, Lyzf3, Lzp-s}, PTPMT1 (protein tyrosine phosphatase mitochondrial 1) [NCBI Gene 114971] {aka DUSP23, MOSP, NEDAXBA, PLIP, PNAS-129}, Epcam (epithelial cell adhesion molecule) [NCBI Gene 17075] {aka CD326, EGP, EGP-2, Egp314, Ep-CAM, EpCAM1}, Col1a1 (collagen, type I, alpha 1) [NCBI Gene 12842] {aka Col1a-1, Cola-1, Cola1, Mov-13, Mov13}, CXCL13 (C-X-C motif chemokine ligand 13) [NCBI Gene 10563] {aka ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L}, SPP1 (secreted phosphoprotein 1) [NCBI Gene 6696] {aka BNSP, BSPI, ETA-1, OPN}, NR4A1 (nuclear receptor subfamily 4 group A member 1) [NCBI Gene 3164] {aka GFRP1, HMR, N10, NAK-1, NGFIB, NP10}, Cd79a (CD79A antigen (immunoglobulin-associated alpha)) [NCBI Gene 12518] {aka Ig-alpha, Iga, Igalpha, Ly-54, Ly54, mb-1}, CD44 (CD44 molecule (IN blood group)) [NCBI Gene 960] {aka CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL}, Fosl1 (fos-like antigen 1) [NCBI Gene 14283] {aka Fra1, fra-1}, MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}, Tcf4 (transcription factor 4) [NCBI Gene 21413] {aka 5730422P05Rik, ASP-I2, E2-2, E2.2, ITF-2, ITF-2b}, TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, Spic (Spi-C transcription factor (Spi-1/PU.1 related)) [NCBI Gene 20728] {aka Prf, Spi-C}, NR4A3 (nuclear receptor subfamily 4 group A member 3) [NCBI Gene 8013] {aka CHN, CSMF, MINOR, NOR1}, BCR (BCR activator of RhoGEF and GTPase) [NCBI Gene 613] {aka ALL, BCR1, CML, D22S11, D22S662, PHL}, TFE3 (transcription factor binding to IGHM enhancer 3) [NCBI Gene 7030] {aka MRXSPF, RCCP2, RCCX1, TFEA, bHLHe33}, BATF (basic leucine zipper ATF-like transcription factor) [NCBI Gene 10538] {aka B-ATF, BATF1, SFA-2, SFA2}
- **Diseases:** cytotoxic (MESH:D064420), Liver metastasis (MESH:D009362), CRC (MESH:D015179), colorectal liver metastatic (MESH:D017093), -cancer (MESH:D009369), diabetic (MESH:D003920), tumorigenesis (MESH:D063646)
- **Chemicals:** amino acid (MESH:D000596), H&E (MESH:D006371), CMC-Na (-), hydrogen (MESH:D006859), carboxymethylcellulose sodium (MESH:D002266), Troglitazone (MESH:D000077288), CTD (MESH:C064089)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12960060/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12960060/full.md

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Source: https://tomesphere.com/paper/PMC12960060