# Cost analysis of hospital-based symptomatic uterine fibroids in the kingdom of Eswatini: A prevalence-based cost-of-illness study

**Authors:** Vuyisile Jabulile Ginindza, Andre Bovell, Makandwe Nyirenda, Themba G. Ginindza

PMC · DOI: 10.1371/journal.pone.0342892 · PLOS One · 2026-03-04

## TL;DR

This study estimates the annual cost of treating uterine fibroids in Eswatini, showing high expenses mainly from surgeries and hospital stays.

## Contribution

The study provides the first prevalence-based cost-of-illness analysis for uterine fibroids in Eswatini.

## Key findings

- The total annual direct medical cost of uterine fibroids in Eswatini is USD 837,894.60.
- Surgical costs (USD 421,583.18) and inpatient costs (USD 110,716.59) are the main cost drivers.
- The findings highlight the financial burden of uterine fibroids on healthcare systems in Eswatini.

## Abstract

Uterine fibroids are common benign tumours of uterine smooth muscle. It has been established that uterine fibroids cause a marked global financial burden on healthcare systems and society; however, significant gaps exist in the knowledge of costs related to uterine fibroids. This study aimed to estimate costs associated with the diagnosis, care, and management of uterine fibroids in Eswatini.

The study employed the Cost of Illness (COI) method, a retrospective prevalence cost model. The provider’s perspective was used to estimate all identifiable direct medical costs of UFs. Data was collected from participants’ charge and claims records from the hospitals between 21 August 2021 and 21 August 2022. The study employed a bottom-up approach to estimate all patient costs related to uterine fibroids care and treatment. The costs were calculated at the 2022 price level and converted to United States dollars (USD) using private-payer prices.

The total annual direct medical cost of uterine fibroids in Eswatini was estimated at USD 837894.60. This includes the total estimated costs of outpatient treatment and care, surgical treatment and care, and inpatient treatment and care. The key cost drivers were surgical and inpatient costs, USD 421583.18 and USD 110716.59, respectively.

The total annual cost estimation of uterine fibroids care is significantly high, with the majority of the cost related to theatre and hospitalisation charges. Understanding these financial implications can help guide healthcare policies and resource management.

## Full-text entities

- **Genes:** COX1 (cytochrome c oxidase subunit I) [NCBI Gene 4512] {aka COI, MTCO1}
- **Diseases:** abdominal pains (MESH:D015746), gynaecological tumours (MESH:D009369), cervical cancer (MESH:D002583), gynaecological benign diseases (MESH:D004194), OOP (MESH:D005888), pelvic mass (MESH:C536030), reproductive system diseases (MESH:D060737), UFS (MESH:C536480), bleeding (MESH:D006470), obesity (MESH:D009765), HMB (MESH:D008595), infertility (MESH:D007246), pelvic pain (MESH:D017699), vaginal bleeding (MESH:D014592), Cost of Illness (MESH:D002908), benign tumours of uterine smooth muscle (MESH:D018235), anaemia (MESH:D000743), UFs (MESH:D007889)
- **Chemicals:** caffeine (MESH:D002110), UKZN (-), silicon (MESH:D012825), alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606], Papillomaviridae (family) [taxon 151340]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12959712/full.md

## References

50 references — full list in the complete paper: https://tomesphere.com/paper/PMC12959712/full.md

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Source: https://tomesphere.com/paper/PMC12959712