# The frequency, risk factors and spatial distribution associated with having a diagnosis of leishmaniosis in dogs in the UK in 2019

## TL;DR

This study examines the prevalence and risk factors of leishmaniosis in UK dogs in 2019, finding that most cases come from imported dogs and are concentrated in southern England.

## Contribution

The study provides updated epidemiological data on leishmaniosis in UK dogs, including breed-specific risk factors and spatial distribution patterns.

## Key findings

- The estimated annual prevalence of leishmaniosis in UK dogs was 0.0434% with 976 cases reported in 2019.
- Most leishmaniosis cases in the UK originated from outside the country, with 60.8% already diagnosed before import.
- Southern England had a higher than expected number of leishmaniosis cases, indicating a spatial clustering.

## Abstract

Leishmaniosis in dogs is an important zoonotic disease, endemic in southern Europe but is increasingly being recorded in other parts of Europe including the UK. This study aimed to update the epidemiological knowledge of leishmaniosis in the UK dog population.

The estimated prevalence of leishmaniosis diagnosis in dogs under care at VetCompass UK participating practices in 2019 was calculated. Risk factor associations for leishmaniosis were investigated using mixed-effects multivariable logistic regression modelling. The spatial distribution of leishmaniosis was explored using standardised morbidity rates (SMR) at regional and county levels, and Moran’s I was used to identify significant spatial autocorrelation.

The estimated annual prevalence was calculated as 0.0434% (95% CI 0.0427–0.0443) with 976 cases from this population of dogs (n = 2,250,741). Most of the dogs with leishmaniosis had originated from outside the UK (955/976, 97.9%) and of those, 60.8% (581) had already been diagnosed with leishmaniosis pre-import. In the risk factor analysis, the odds of leishmaniosis were higher in males (OR 1.29, 95% CI 1.12–1.49) and neutered dogs (OR 6.42, 95% CI 4.43–9.29) compared to female and entire dogs, respectively. Purebreds overall had lower odds of leishmaniosis compared to crossbreeds (OR 0.24, 95% CI 0.20–0.28) but there were specific breeds such as Brittany Spaniels (OR 53.0, 95% CI 25.3–111.1), Ibizan Hounds (OR 43.8, 95% CI 9.20–208.3) and English Pointers (OR 28.6, 95% CI 14.5–56.4) which had much higher odds of being a case compared to crossbreeds. Spatial analysis identified more leishmaniosis cases in southern England than were expected by random chance (SMR > 1).

This study identifies that imported animals are the commonest source of dogs having a leishmaniosis diagnosis. The breeds with very high odds for leishmaniosis may reflect selection bias towards breeds more likely to be imported, rescued or travelled from endemic areas rather than high intrinsic risk in these breeds towards leishmaniosis. These results support and update previous studies indicating that most cases are diagnosed in southern England.