This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression
Abstract
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Taxonomy
TopicsVirus-based gene therapy research · Viral Infectious Diseases and Gene Expression in Insects · Cancer Research and Treatments
After this article [1] was published, concerns were raised about the reported mouse tumor sizes. Specifically:
In response to editorial follow-up, the corresponding author stated that mice were euthanized if they had tumors exceeding 4,000 mm^3^ and >20% body weight loss, or if two or more mice had tumors exceeding 4,000 mm^3^ with ≤ 20% body weight loss.
The PLOS One Editors remain concerned that the endpoint criteria do not align with internationally accepted animal welfare standards for mouse tumor studies. Therefore, the PLOS One Editors retract this article [1].
The ethics approval document number was not reported in [1]. The corresponding author stated the approval numbers from the Ethics Review Committee for Animal Experimentation of Okayama University School of Medicine for the study in [1] are OKU-2018319 and OKU-2018789.
TOmori, HT, YY, SO, JH, KS, TomohiroF, AY, TKunisada, SK, TOzaki, and ToshiyoshiF agreed with the retraction. TKomatsubara and YU either did not respond directly or could not be reached.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Omori T, Tazawa H, Yamakawa Y, Osaki S, Hasei J, Sugiu K, et al. RETRACTED: Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL 1 expression. P Lo S One. 2021;16(4):e 0250643. doi: 10.1371/journal.pone.0250643 33886686 PMC 8061981 · doi ↗ · pubmed ↗