# Salmonella Stanley ST29 carrying IncHI2/ST3-blaNDM-5 plasmid emerged in a 4-month-old infant with diarrhea

## TL;DR

A 4-month-old infant's Salmonella infection revealed a rare carbapenem-resistant plasmid and insights into its spread in the community.

## Contribution

The study identifies a novel plasmid-mediated blaNDM-5 carbapenem resistance in Salmonella Stanley ST29 and its potential community spread.

## Key findings

- Two clonal ST29 isolates showed Tn7051-mediated excision of blaNDM-5 from an IncHI2/ST3 plasmid.
- Phylogenomic analysis linked the isolate to strains from a healthy carrier and food sources in the same region.
- Findings highlight the need for One-Health surveillance to track emerging Salmonella Stanley ST29.

## Abstract

Salmonella serovar Stanley ST29 is an emerging foodborne pathogen with community spread potential, while its carbapenem resistance remains uncommon. In a longitudinal pediatric case with diarrhea, two clonal ST29 isolates sampled 2 months apart revealed within-host evolutionary dynamics: Tn7051-mediated excision of blaNDM-5 from an IncHI2/ST3 plasmid. Moreover, phylogenomics connected the case isolate to strains from a healthy carrier and from food-chain-associated sources in the same region (17–18 SNPs), underscoring community dissemination and the need for One-Health surveillance.