# Antischistosomal activity of imidazolidine-2,4-dione derivatives

## TL;DR

Researchers tested new compounds for treating schistosomiasis and found some effective and safe options.

## Contribution

Identified imidazolidine-2,4-dione derivatives as a novel scaffold with antischistosomal activity.

## Key findings

- Four imidazolidine-2,4-dione derivatives showed selective antischistosomal activity.
- These compounds had low cytotoxicity in mammalian cells.
- Isoindole-1,3-dione derivatives were ineffective against the parasite.

## Abstract

Schistosomiasis is a neglected tropical disease with limited treatment options and growing concerns over praziquantel resistance. We evaluated a series of 12 synthetic compounds for antiparasitic activity against Schistosoma mansoni adult worms in vitro. Isoindole-1,3-dione derivatives were inactive, whereas four imidazolidine-2,4-dione derivatives displayed selective antischistosomal activity with low cytotoxicity in mammalian cells. These findings highlight imidazolidine-2,4-dione as a promising scaffold for the development of new therapeutic agents against schistosomiasis.