# Variable chlorhexidine MICs across Klebsiella species from a single facility

## TL;DR

This study found varying levels of resistance to chlorhexidine among different Klebsiella species in a hospital, which could affect microbial populations.

## Contribution

The study reveals species-specific differences in chlorhexidine resistance and potential chromosomal factors involved.

## Key findings

- Klebsiella quasipneumoniae showed the highest chlorhexidine MICs.
- No clear link to acquired resistance was found, but some species had more chromosomal efflux pumps.
- Chlorhexidine MIC differences suggest biocides influence hospital microbial populations.

## Abstract

We assessed in vitro chlorhexidine minimal inhibitory concentrations (MICs) across Klebsiella species from a hospital with widespread chlorhexidine use. Isolates underwent MIC testing and whole genome sequencing. Species showed varying resistance, with Klebsiella quasipneumoniae having the highest MICs. There was no clear link to acquired resistance, but some species had more chromosomal efflux pumps. Differences in chlorhexidine MICs between species highlight the role that biocides could have in shaping microbial populations in the hospital environment.