# Gut bacteriome alterations during high altitude exposure: a comprehensive analysis of different species

## TL;DR

This study reviews how gut bacteria change in different species when exposed to high-altitude hypoxia and identifies key bacteria that may help hosts adapt.

## Contribution

The paper provides a comprehensive analysis of gut bacteriome alterations across species in high-altitude environments.

## Key findings

- Gut bacteriome diversity and composition vary in different highland hypoxic environments.
- A core bacteriome associated with host adaptation to hypoxia was identified.
- Multiple factors influence gut bacteriome dynamics during high-altitude exposure.

## Abstract

With the increase of high-altitude sojourn population, more and more studies on hypoxia have been conducted, but the associated changes in gut bacteriome in different hypoxic environments need to be further investigated. Gut bacteriome plays an important role in host adaptation to high-altitude hypoxia, but the contribution of gut bacteriome in high-altitude hypoxia adaptation is still controversial and may be influenced by multiple factors. In this study, we reviewed the changes in diversity and composition of the gut bacteriome of different populations of animals in different highland hypoxic environments, clarified the dynamics of the gut bacteriome during exposure to high altitude, identified the core bacteriome that may contribute to host adaptation to hypoxic environments, and comprehensively considered the effects of multiple factors on the gut bacteriome.