# Hypereosinophilia Associated With Antisynthetase Syndrome With Anti‐Ro52/PL12 Co‐Positivity: An Unusual Presentation

## TL;DR

This paper discusses a rare case of a condition involving high eosinophil levels and an autoimmune disease, highlighting challenges in diagnosis and disease severity.

## Contribution

The study identifies a rare association between hypereosinophilia and antisynthetase syndrome with anti-Ro52/PL12 co-positivity.

## Key findings

- Hypereosinophilia is uncommon in antisynthetase syndrome and complicates diagnosis.
- Anti-PL12's role in interstitial lung disease severity is debated but linked to a more severe disease phenotype when associated with anti-Ro52.
- African ethnicity may be a negative prognostic factor for lung disease severity.

## Abstract

Hypereosinophilia is uncommon in ASS and this presentation makes diagnosis more challenging. Anti‐PL12's role in the severity of ILD is controversial but its association with anti‐Ro52 seems to give a more serious disease phenotype. African ethnicity could be a negative prognostic factor, associated with lung disease severity.