# Facial Melanosis in Skin of Color: An Integrated Clinical, Dermoscopic, and Quality of Life Analysis

**Authors:** Aniket Goswami, Anita Marak, Shikha Verma, Bikash Chingshubam, Saqib Raza Hasan Khan

PMC · DOI: 10.7759/cureus.102816 · Cureus · 2026-02-02

## TL;DR

This study explores pigmentary disorders in skin of color, combining clinical, dermoscopic, and quality of life assessments to better understand their impact.

## Contribution

The study uniquely integrates atypical dermoscopic features with quality of life analysis in facial melanosis of skin of color.

## Key findings

- Melasma was the most common diagnosis, with a strong female predominance.
- Atypical dermoscopic features were identified, which are rarely reported in facial melanosis.
- Patients showed significant emotional burden despite low symptom scores.

## Abstract

Background: Facial melanosis comprises a heterogeneous spectrum of pigmentary disorders that are particularly prevalent and persistent in skin of color. Despite its frequency, comprehensive data integrating clinical patterns, dermoscopic features, and quality of life impact remain limited, especially from Northeast India.

Objectives: This study aimed to characterize the clinical spectrum of facial melanosis, delineate dermoscopic patterns, including atypical features, and evaluate health-related quality of life using Skindex-16 in a skin of color population.

Materials and methods: This hospital-based cross-sectional study included 150 untreated adults with facial melanosis. Participants underwent detailed clinical evaluation, dermoscopic assessment using a polarized video dermoscope, and quality of life assessment with Skindex-16. Diagnoses were classified as standalone or overlapping entities.

Results: Twenty-two clinical conditions were identified, with melasma being the most prevalent diagnosis (n = 102, 68.0%), showing a marked female preponderance. Overlapping presentations, particularly melasma with topical steroid damaged face (TSDF), were common. Dermoscopy revealed predominant pigmentary patterns such as brown structureless areas and globules, alongside vascular and appendageal changes. Importantly, infrequent atypical dermoscopic features, rarely reported in facial melanosis, were documented. Quality of life analysis demonstrated a disproportionate emotional burden despite relatively low symptom scores.

Conclusion: Facial melanosis in skin of color is clinically complex, frequently overlapping, and psychosocially impactful. The integration of dermoscopy and quality of life assessment provides a nuanced, patient-centered understanding, with the identification of atypical dermoscopic features representing a distinctive contribution of this study.

## Full-text entities

- **Diseases:** erythrosis pigmentosa peribuccalis of Brocq (MESH:C538603), drug eruption (MESH:D003875), 's nevus (MESH:D009506), Mucosal lentigines (MESH:D007911), TSDF (MESH:C536384), varicella (MESH:D002644), Pigmentation (MESH:D010859), nevus spilus (MESH:C536819), pigmentary disease (MESH:D004194), trauma (MESH:D014947), inflammation (MESH:D007249), LPP (MESH:D008010), CLD (MESH:D008107), facial pigmentary disorders (MESH:D005155), ashy dermatosis (MESH:D012871), PIH (MESH:D017495), pain (MESH:D010146), Hypothyroidism (MESH:D007037), Facial melanosis (MESH:D008548), EMFFEC (MESH:C537377), Erythema (MESH:D004890), pigmentary disorders (MESH:C535508), AN (MESH:D000052), PDL (MESH:D006432), dermal pigmentary disorders (MESH:D016136), XP (MESH:D014983), SLE (MESH:D008180), IV (MESH:D006011), Erythrosis pigmentosa peribuccalis (MESH:D012174), hypertrichosis (MESH:D006983), Nevus of Ota (MESH:D009507)
- **Chemicals:** eumelanin (MESH:C041877), oils (MESH:D009821), propranolol (MESH:D011433), POH (-), rifaximin (MESH:D000078262), hydroxychloroquine (MESH:D006886), isopropyl alcohol (MESH:D019840), alcohol (MESH:D000438), mustard oil (MESH:C027793), steroid (MESH:D013256), fluconazole (MESH:D015725), melanin (MESH:D008543)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12958090/full.md

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12958090/full.md

## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC12958090/full.md

---
Source: https://tomesphere.com/paper/PMC12958090