# West African tick-borne relapsing fever, a neglected disease of major public health importance in Senegal

**Authors:** El Hadji Ibrahima NDIAYE, Georges DIATTA, Cheikh SOKHNA, Philippe PAROLA

PMC · DOI: 10.48327/mtsi.v5i4.2025.573 · Médecine Tropicale et Santé Internationale · 2025-09-24

## TL;DR

This paper highlights the under-recognized public health threat of tick-borne relapsing fever in Senegal, emphasizing its causes, transmission, and control strategies.

## Contribution

The study provides a comprehensive overview of the epidemiology, clinical aspects, and control measures for relapsing fever in West Africa, focusing on Senegal.

## Key findings

- Relapsing fever caused by Borrelia crocidurae is underdiagnosed in Senegal due to lack of awareness among health professionals and the public.
- Small wild mammals serve as reservoir hosts for the pathogen, and tick distribution is mapped for better understanding.
- Control strategies include habitat modification and public awareness campaigns to reduce transmission.

## Abstract

La fièvre récurrente à tiques (FRT), est une zoonose causée par diverses espèces de Borrelia transmises aux humains à travers le monde, par la piqûre des tiques molles du genre Ornithodoros. Au Sénégal, comme dans les autres régions endémiques d’Afrique de l’Ouest, les cas de FRT, causés par Borrelia cro-cidurae et transmis par les tiques Ornithodoros sonrai, sont sous-diagnostiqués. La maladie reste peu connue des médecins, des infirmiers et des populations. Dans certaines régions, la FRT est devant le paludisme dans les causes de fièvre à transmission vectorielle.

Cette revue narrative et systématique rapporte des données entomologiques, mammalogiques, épidémiologiques et les aspects cliniques connus de la maladie au Sénégal. Les petits mammifères sauvages, principaux hôtes réservoirs de B. crocidurae ont été répertoriés et cartographiés, ainsi que la répartition connue des tiques vectrices. Les méthodes de diagnostic classique comme la visualisation des spirochètes sur une goutte épaisse de sang et/ou un frottis sanguin, mais aussi les méthodes modernes de biologie moléculaire sont décrites, ainsi que le traitement antibiotique.

La stratégie de prévention et de lutte contre la FRT au Sénégal repose sur l’amélioration des conditions d’habitat traditionnel, le remblaiement des terriers et la capture des petits mammifères dans les habitations humaines. Ces méthodes doivent être mieux connues et vulgarisées à travers des campagnes de sensibilisation dans les régions endémiques par les autorités sanitaires.

## Linked entities

- **Diseases:** relapsing fever (MONDO:0019633), malaria (MONDO:0005136)
- **Species:** Ornithodoros sonrai (taxon 352064), Borrelia crocidurae (taxon 29520)

## Full-text entities

- **Diseases:** miscarriage (MESH:D000022), parasitic diseases (MESH:D010272), muscle and bone pain (MESH:D063806), vector-borne disease (MESH:D000079426), malaria (MESH:D008288), ocular disorders (MESH:D005128), facial paralysis (MESH:D005158), relapsing typhus (MESH:D014438), anemia (MESH:D000740), back pain (MESH:D001416), Borrelia (MESH:D001899), death (MESH:D003643), drop in blood pressure (MESH:D006973), chills (MESH:D023341), Larrey's relapsing fever syndrome (MESH:D012061), abortions (MESH:D000026), bacteremia (MESH:D016470), -infections (MESH:D007239), digestive disorders (MESH:D004066), vascular damage (MESH:D057772), arthralgia (MESH:D018771), febrile (MESH:D000071072), hepato-splenomegalie (MESH:D013163), eye damage (MESH:D005131), diarrhea (MESH:D003967), NTDs (MESH:D058069), TDR (MESH:D013736), Fever (MESH:D005334), neuroborreliosis (MESH:D020852), meningo-encephalites (MESH:D010301), vomiting (MESH:D014839), B. crocidurae infection (MESH:D006566), inflammatory (MESH:D007249), headache (MESH:D006261), Q fever (MESH:D011778), MTN (MESH:C535802), P. h. capitis (MESH:D014006), influenza (MESH:D007251), bone pain (MESH:D010146), meningoencephalitis (MESH:D008590), Hepatosplenomegaly (MESH:C535727), Lyme borreliosis (MESH:D008193), tick-borne borreliosis (MESH:D017282), abdominal pain (MESH:D015746), hepatorenal syndrome (MESH:D006530)
- **Chemicals:** tryparsamide (MESH:C073345), glutaraldehyde (MESH:D005976), B. crocidurae (-), penicillin (MESH:D010406), ceftriaxone (MESH:D002443), rifampicin (MESH:D012293), diamidine (MESH:D010419), Giemsa (MESH:D001399), acetylsalicylic acid (MESH:D001241), silver (MESH:D012834), Erythromycin (MESH:D004917), amoxicillin (MESH:D000658), azithromycin (MESH:D017963), doxycycline (MESH:D004318), sulfonamides (MESH:D013449), metronidazole (MESH:D008795)
- **Species:** Ornithodoros moubata (species) [taxon 6938], Ornithodoros costalis (species) [taxon 1339068], Ixodida (ticks, order) [taxon 6935], Cricetomys gambianus (Gambian giant pouched rat, species) [taxon 10085], Ehrlichia (genus) [taxon 943], Borrelia (Relapsing Fever Borrelia, genus) [taxon 138], Borrelia recurrentis (species) [taxon 44449], Coxiella burnetii (species) [taxon 777], Rattus rattus (black rat, species) [taxon 10117], Ornithodoros turicata (species) [taxon 34597], Orussus occidentalis (species) [taxon 576952], [Borrelia] lusitaniae (species) [taxon 100177], Ornithodoros porcinus (species) [taxon 34594], Bartonella (genus) [taxon 773], Wolbachia (genus) [taxon 953], Ornithodoros parkeri (species) [taxon 140564], Borrelia hispanica (species) [taxon 40835], Borrelia duttonii (species) [taxon 40834], Mus musculus domesticus (western European house mouse, subspecies) [taxon 10092], Dasymys incomtus (African marsh rat, species) [taxon 71173], Occidentia massiliensis (species) [taxon 752179], Borrelia merionesi (species) [taxon 1239297], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606], Borrelia hermsii (species) [taxon 140], Ornithodoros erraticus (species) [taxon 265619], Plasmodium falciparum (malaria parasite P. falciparum, species) [taxon 5833], Rodentia (rodent, order) [taxon 9989], Ornithodoros sonrai (species) [taxon 352064], Mastomys sp. (species) [taxon 70830], Mastomys natalensis (African soft-furred rat, species) [taxon 10112], Gerbillus tarabuli (Tarabul's gerbil, species) [taxon 856706], Arvicanthis niloticus (African grass rat, species) [taxon 61156], Gerbillus occiduus (occidental gerbil, species) [taxon 1100085], Atelerix albiventris (four-toed hedgehog, species) [taxon 9368], Ornithodoros tholozani (species) [taxon 554291], Anaplasma (genus) [taxon 768], Pediculus humanus corporis (human body lice, subspecies) [taxon 121224], Crocidura olivieri (African giant shrew, species) [taxon 214449], Ornithodoros rupestris (species) [taxon 1339072], Borreliella garinii (Borrelia genomic group 20047, species) [taxon 29519], Borreliella afzelii (Borrellia group VS461, species) [taxon 29518], Mastomys erythroleucus (Guinea multimammate mouse, species) [taxon 41268], Pediculus humanus (body lice, species) [taxon 121225], Praomys daltoni (Dalton's mouse, species) [taxon 10113], Gerbillus sp. (species) [taxon 10187], Desmodilliscus braueri (pouched gerbil, species) [taxon 298892], Borreliella burgdorferi (Lyme disease spirochete, species) [taxon 139], Ornithodoros kairouanensis (species) [taxon 1339069], Gerbilliscus gambianus (species) [taxon 41264], Heliosciurus gambianus (Gambian sun squireel, species) [taxon 1235482], Borrelia crocidurae (species) [taxon 29520], Ornithodoros merionesi (species) [taxon 1339070], Ornithodoros marocanus (species) [taxon 1337745], Ornithodoros occidentalis (species) [taxon 1339071], Rickettsiaceae (family) [taxon 775], Mus musculus (house mouse, species) [taxon 10090], Taterillus gracilis (slender gerbil, species) [taxon 298890], Gerbillus nigeriae (Nigerian gerbil, species) [taxon 39472]

## Full text

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## Figures

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## References

123 references — full list in the complete paper: https://tomesphere.com/paper/PMC12957993/full.md

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Source: https://tomesphere.com/paper/PMC12957993