# The information challenge in public health crises: a study on the reliability and readability of information provided by large language model for thunderstorm asthma

**Authors:** Zhenliang Zhu, Yanghui Feng, Feng Cao

PMC · DOI: 10.3389/fpubh.2026.1776697 · Frontiers in Public Health · 2026-02-18

## TL;DR

This study evaluates how reliable and easy to understand health information about thunderstorm asthma is when generated by large language models like ChatGPT and Microsoft Copilot.

## Contribution

The study introduces a comprehensive evaluation of LLM-generated health information using both reliability and readability metrics for thunderstorm asthma.

## Key findings

- Microsoft Copilot outperformed other models in reliability and structural quality of responses.
- All models failed to meet sixth-grade readability standards, making information too complex for the general public.

## Abstract

The advent of LLM (large language model) has seen extensive application in health information consultation, enabling interactive responses to complex queries; however, their reliability and readability warrant further investigation. This study aims to assess the reliability and readability of cross-disciplinary responses generated by artificial intelligence platforms regarding thunderstorm asthma, including ChatGPT-4, Deepseek-V3.2-V3.2, Perplexity Pro, and Microsoft Copilot.

This study uses Google Trends to identify and filter topic-specific information on thunderstorm asthma. This study analyses cross-disciplinary responses generated by ChatGPT-4, Deepseek-V3.2, Perplexity Pro, and Microsoft Copilot in response to conversational inputs. The 29 selected responses exhibit varying levels of meteorological forecasting accuracy concerning thunderstorms, as well as prevalent themes related to asthma symptomatology and therapeutic interventions. The study employed reliability assessment tools, including the DISCERN instrument, the Ensuring Quality Information for Patients Scale (EQIP), the JAMA benchmarks, and the Global Quality Scoring (GQS), in conjunction with six authoritative readability metrics—namely, the Automated Readability Index (ARI), Coleman-Liau Grade Level (CL), Flesch–Kincaid Grade Level (FKGL), Flesch Reading Ease Score (FRES), Gunning Fog Index (GFI), and SMOG—to enable a comprehensive evaluation.

Research findings indicate statistically significant differences in the reliability of various artificial intelligence programmes when responding to complex interdisciplinary information queries. Microsoft Copilot demonstrates superior performance in terms of information reliability and structural quality, consistently achieving higher scores than ChatGPT-4-4o and Perplexity Pro, thereby providing more dependable information. However, all programme-generated informational responses were excessively complex for the general public, failing to meet sixth-grade reading comprehension standards, as the majority of outputs were written at a secondary education level or higher.

This study reveals that while LLM demonstrate some reliability in handling complex health consultations, none meet the recommended readability benchmark for a sixth-grade reading level. Future efforts should focus on improving the reliability and readability of LLM generated health information to enhance comprehension amongst broader audiences.

## Full-text entities

- **Diseases:** LLM (MESH:D007806), respiratory distress (MESH:D012128), Asthma (MESH:D001249), Asthma storm (MESH:C566109), airway spasm (MESH:D013035), ARI (MESH:C566784), fatalities (MESH:C565541)
- **Chemicals:** Budesonide (MESH:D019819), LLM (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

33 references — full list in the complete paper: https://tomesphere.com/paper/PMC12957218/full.md

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Source: https://tomesphere.com/paper/PMC12957218